Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms

Damian E. Dupuy, Andrew Rosenberg, Thipachart Punyaratabandhu, Mann Hong Tan, Henry J. Mankin

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of our study was to assess the accuracy of CT- guided biopsy of musculoskeletal neoplasms with respect to technique, anatomic site, and histology. MATERIALS AND METHODS. During a 3-year period (January 1992 to December 1994), 176 core needle biopsies and 45 fine-needle aspirations were performed under CT guidance on patients with musculoskeletal neoplasms. To assess the accuracy of these procedures, we compared the diagnosis at biopsy with the final diagnosis as determined at the time of definitive treatment of the lesion. All biopsy findings were categorized as a primary malignancy (excluding round cell lesions), round cell lesion, local recurrence, or metastatic carcinoma. In addition, each lesion was analyzed according to which biopsy technique was used, whether frozen tissue section or rapid cytologic evaluation was used, and at which anatomic site the mass was found. RESULTS. The accuracy for needle biopsy was 93% and that for fine- needle aspiration was 80%. The complication rate for both techniques was less than 1%. Accuracy rates for the four categories of primary malignancy, round cell lesion, local recurrence, and metastatic carcinoma were 87%, 75%, 94%, and 100%, respectively. The mismatch rates were similar in soft-tissue lesions (5/52) and bone lesions (16/169). Diminished accuracy was associated with round cell lesions (20%) and lesions located in the spine or the perivertebral region (20%). Nondiagnostic and insufficient specimens were found in 18 (8%) of the 221 patients. CONCLUSION. CT-guided biopsy of musculoskeletal malignancies is a safe and effective procedure if performed by a team of clinicians, pathologists, and radiologists who possess subspecialty expertise.

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalAmerican Journal of Roentgenology
Volume171
Issue number3
StatePublished - Sep 1 1998
Externally publishedYes

Fingerprint

Needle Biopsy
Biopsy
Neoplasms
Fine Needle Biopsy
Carcinoma
Large-Core Needle Biopsy
Recurrence
Frozen Sections
Histology
Spine
Bone and Bones

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Dupuy, D. E., Rosenberg, A., Punyaratabandhu, T., Tan, M. H., & Mankin, H. J. (1998). Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms. American Journal of Roentgenology, 171(3), 759-762.

Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms. / Dupuy, Damian E.; Rosenberg, Andrew; Punyaratabandhu, Thipachart; Tan, Mann Hong; Mankin, Henry J.

In: American Journal of Roentgenology, Vol. 171, No. 3, 01.09.1998, p. 759-762.

Research output: Contribution to journalArticle

Dupuy, DE, Rosenberg, A, Punyaratabandhu, T, Tan, MH & Mankin, HJ 1998, 'Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms', American Journal of Roentgenology, vol. 171, no. 3, pp. 759-762.
Dupuy DE, Rosenberg A, Punyaratabandhu T, Tan MH, Mankin HJ. Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms. American Journal of Roentgenology. 1998 Sep 1;171(3):759-762.
Dupuy, Damian E. ; Rosenberg, Andrew ; Punyaratabandhu, Thipachart ; Tan, Mann Hong ; Mankin, Henry J. / Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms. In: American Journal of Roentgenology. 1998 ; Vol. 171, No. 3. pp. 759-762.
@article{ecd810abc1b944bb86dc7929512f551f,
title = "Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms",
abstract = "OBJECTIVE. The purpose of our study was to assess the accuracy of CT- guided biopsy of musculoskeletal neoplasms with respect to technique, anatomic site, and histology. MATERIALS AND METHODS. During a 3-year period (January 1992 to December 1994), 176 core needle biopsies and 45 fine-needle aspirations were performed under CT guidance on patients with musculoskeletal neoplasms. To assess the accuracy of these procedures, we compared the diagnosis at biopsy with the final diagnosis as determined at the time of definitive treatment of the lesion. All biopsy findings were categorized as a primary malignancy (excluding round cell lesions), round cell lesion, local recurrence, or metastatic carcinoma. In addition, each lesion was analyzed according to which biopsy technique was used, whether frozen tissue section or rapid cytologic evaluation was used, and at which anatomic site the mass was found. RESULTS. The accuracy for needle biopsy was 93{\%} and that for fine- needle aspiration was 80{\%}. The complication rate for both techniques was less than 1{\%}. Accuracy rates for the four categories of primary malignancy, round cell lesion, local recurrence, and metastatic carcinoma were 87{\%}, 75{\%}, 94{\%}, and 100{\%}, respectively. The mismatch rates were similar in soft-tissue lesions (5/52) and bone lesions (16/169). Diminished accuracy was associated with round cell lesions (20{\%}) and lesions located in the spine or the perivertebral region (20{\%}). Nondiagnostic and insufficient specimens were found in 18 (8{\%}) of the 221 patients. CONCLUSION. CT-guided biopsy of musculoskeletal malignancies is a safe and effective procedure if performed by a team of clinicians, pathologists, and radiologists who possess subspecialty expertise.",
author = "Dupuy, {Damian E.} and Andrew Rosenberg and Thipachart Punyaratabandhu and Tan, {Mann Hong} and Mankin, {Henry J.}",
year = "1998",
month = "9",
day = "1",
language = "English",
volume = "171",
pages = "759--762",
journal = "AJR. American journal of roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "3",

}

TY - JOUR

T1 - Accuracy of CT-guided needle biopsy of musculoskeletal neoplasms

AU - Dupuy, Damian E.

AU - Rosenberg, Andrew

AU - Punyaratabandhu, Thipachart

AU - Tan, Mann Hong

AU - Mankin, Henry J.

PY - 1998/9/1

Y1 - 1998/9/1

N2 - OBJECTIVE. The purpose of our study was to assess the accuracy of CT- guided biopsy of musculoskeletal neoplasms with respect to technique, anatomic site, and histology. MATERIALS AND METHODS. During a 3-year period (January 1992 to December 1994), 176 core needle biopsies and 45 fine-needle aspirations were performed under CT guidance on patients with musculoskeletal neoplasms. To assess the accuracy of these procedures, we compared the diagnosis at biopsy with the final diagnosis as determined at the time of definitive treatment of the lesion. All biopsy findings were categorized as a primary malignancy (excluding round cell lesions), round cell lesion, local recurrence, or metastatic carcinoma. In addition, each lesion was analyzed according to which biopsy technique was used, whether frozen tissue section or rapid cytologic evaluation was used, and at which anatomic site the mass was found. RESULTS. The accuracy for needle biopsy was 93% and that for fine- needle aspiration was 80%. The complication rate for both techniques was less than 1%. Accuracy rates for the four categories of primary malignancy, round cell lesion, local recurrence, and metastatic carcinoma were 87%, 75%, 94%, and 100%, respectively. The mismatch rates were similar in soft-tissue lesions (5/52) and bone lesions (16/169). Diminished accuracy was associated with round cell lesions (20%) and lesions located in the spine or the perivertebral region (20%). Nondiagnostic and insufficient specimens were found in 18 (8%) of the 221 patients. CONCLUSION. CT-guided biopsy of musculoskeletal malignancies is a safe and effective procedure if performed by a team of clinicians, pathologists, and radiologists who possess subspecialty expertise.

AB - OBJECTIVE. The purpose of our study was to assess the accuracy of CT- guided biopsy of musculoskeletal neoplasms with respect to technique, anatomic site, and histology. MATERIALS AND METHODS. During a 3-year period (January 1992 to December 1994), 176 core needle biopsies and 45 fine-needle aspirations were performed under CT guidance on patients with musculoskeletal neoplasms. To assess the accuracy of these procedures, we compared the diagnosis at biopsy with the final diagnosis as determined at the time of definitive treatment of the lesion. All biopsy findings were categorized as a primary malignancy (excluding round cell lesions), round cell lesion, local recurrence, or metastatic carcinoma. In addition, each lesion was analyzed according to which biopsy technique was used, whether frozen tissue section or rapid cytologic evaluation was used, and at which anatomic site the mass was found. RESULTS. The accuracy for needle biopsy was 93% and that for fine- needle aspiration was 80%. The complication rate for both techniques was less than 1%. Accuracy rates for the four categories of primary malignancy, round cell lesion, local recurrence, and metastatic carcinoma were 87%, 75%, 94%, and 100%, respectively. The mismatch rates were similar in soft-tissue lesions (5/52) and bone lesions (16/169). Diminished accuracy was associated with round cell lesions (20%) and lesions located in the spine or the perivertebral region (20%). Nondiagnostic and insufficient specimens were found in 18 (8%) of the 221 patients. CONCLUSION. CT-guided biopsy of musculoskeletal malignancies is a safe and effective procedure if performed by a team of clinicians, pathologists, and radiologists who possess subspecialty expertise.

UR - http://www.scopus.com/inward/record.url?scp=0031753903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031753903&partnerID=8YFLogxK

M3 - Article

C2 - 9725312

AN - SCOPUS:0031753903

VL - 171

SP - 759

EP - 762

JO - AJR. American journal of roentgenology

JF - AJR. American journal of roentgenology

SN - 0361-803X

IS - 3

ER -