Abstract
After the data collection phase of a clinical trial has been completed, new hypotheses may surface which require additional data before they can be tested. In the Veterans Affairs Cooperative Study on Single Drug Therapy of Hypertension, we investigated the relationship between location of the participating center, race and ability to control blood pressure. The analysis indicated poorer blood pressure control among sites located in the 'stroke belt' (southeastern United States), especially among African- Americans. We sought to determine whether the effect was attributable to socioeconomic patterns; however, income data were not collected as part of the original study. Therefore, we accessed centralized data bases to obtain zipcode-level income information for the randomized study patients. This approach yielded estimates of income data for 94.3% of the patients and compared favorably to data acquisition rates for variables which were collected prospectively in the study.
| Original language | English |
|---|---|
| Pages (from-to) | 183-188 |
| Number of pages | 6 |
| Journal | Journal of Medical Systems |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| State | Published - Nov 17 1999 |
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Keywords
- Centralized data bases
- Clinical trials
- Data acquisition rates
- Data collection
- Hypertension
- National VAMC Outpatient Care File
- Socioeconomic patterns
- Stroke belt
ASJC Scopus subject areas
- Biophysics
Cite this
Accessing data from external centralized sources to enhance analysis of a completed clinical trial. / Abdellatif, Mazen; Reda, Domenic J.; Williams, David; Cushman, William C.; Materson, Barry J.
In: Journal of Medical Systems, Vol. 23, No. 3, 17.11.1999, p. 183-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accessing data from external centralized sources to enhance analysis of a completed clinical trial
AU - Abdellatif, Mazen
AU - Reda, Domenic J.
AU - Williams, David
AU - Cushman, William C.
AU - Materson, Barry J
PY - 1999/11/17
Y1 - 1999/11/17
N2 - After the data collection phase of a clinical trial has been completed, new hypotheses may surface which require additional data before they can be tested. In the Veterans Affairs Cooperative Study on Single Drug Therapy of Hypertension, we investigated the relationship between location of the participating center, race and ability to control blood pressure. The analysis indicated poorer blood pressure control among sites located in the 'stroke belt' (southeastern United States), especially among African- Americans. We sought to determine whether the effect was attributable to socioeconomic patterns; however, income data were not collected as part of the original study. Therefore, we accessed centralized data bases to obtain zipcode-level income information for the randomized study patients. This approach yielded estimates of income data for 94.3% of the patients and compared favorably to data acquisition rates for variables which were collected prospectively in the study.
AB - After the data collection phase of a clinical trial has been completed, new hypotheses may surface which require additional data before they can be tested. In the Veterans Affairs Cooperative Study on Single Drug Therapy of Hypertension, we investigated the relationship between location of the participating center, race and ability to control blood pressure. The analysis indicated poorer blood pressure control among sites located in the 'stroke belt' (southeastern United States), especially among African- Americans. We sought to determine whether the effect was attributable to socioeconomic patterns; however, income data were not collected as part of the original study. Therefore, we accessed centralized data bases to obtain zipcode-level income information for the randomized study patients. This approach yielded estimates of income data for 94.3% of the patients and compared favorably to data acquisition rates for variables which were collected prospectively in the study.
KW - Centralized data bases
KW - Clinical trials
KW - Data acquisition rates
KW - Data collection
KW - Hypertension
KW - National VAMC Outpatient Care File
KW - Socioeconomic patterns
KW - Stroke belt
UR - http://www.scopus.com/inward/record.url?scp=0032722351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032722351&partnerID=8YFLogxK
U2 - 10.1023/A:1020567403785
DO - 10.1023/A:1020567403785
M3 - Article
C2 - 10554734
AN - SCOPUS:0032722351
VL - 23
SP - 183
EP - 188
JO - Journal of Medical Systems
JF - Journal of Medical Systems
SN - 0148-5598
IS - 3
ER -