Accelerating stem cell trials for Alzheimer's disease

Joshua G. Hunsberger, Mahendra Rao, Joanne Kurtzberg, Jeff W.M. Bulte, Anthony Atala, Frank M. LaFerla, Henry T. Greely, Akira Sawa, Sam Gandy, Lon S. Schneider, P. Murali Doraiswamy

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

At present, no effective cure or prophylaxis exists for Alzheimer's disease. Symptomatic treatments are modestly effective and offer only temporary benefit. Advances in induced pluripotent stem cell (iPSC) technology have the potential to enable development of so-called disease-in-a-dish personalised models to study disease mechanisms and reveal new therapeutic approaches, and large panels of iPSCs enable rapid screening of potential drug candidates. Different cell types can also be produced for therapeutic use. In 2015, the US Food and Drug Administration granted investigational new drug approval for the first phase 2A clinical trial of ischaemia-tolerant mesenchymal stem cells to treat Alzheimer's disease in the USA. Similar trials are either underway or being planned in Europe and Asia. Although safety and ethical concerns remain, we call for the acceleration of human stem cell-based translational research into the causes and potential treatments of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)219-230
Number of pages12
JournalThe Lancet Neurology
Volume15
Issue number2
DOIs
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Clinical Neurology

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    Hunsberger, J. G., Rao, M., Kurtzberg, J., Bulte, J. W. M., Atala, A., LaFerla, F. M., Greely, H. T., Sawa, A., Gandy, S., Schneider, L. S., & Doraiswamy, P. M. (2016). Accelerating stem cell trials for Alzheimer's disease. The Lancet Neurology, 15(2), 219-230. https://doi.org/10.1016/S1474-4422(15)00332-4