Abstracts

P. Gkogkolou, M. Sarna, T. Sarna, Ralf Paus, T. A. Luger, M. Böhm

Research output: Contribution to journalArticle

Abstract

Diabetes is a common disease affecting millions of people worldwide. It is characterized by increased glucose concentrations in the blood and body. Chronic foot ulcers are one of the most serious complications in diabetes, affecting up to 10% of diabetic patients. Treatment of these ulcers remains difficult, resulting in high costs for healthcare systems as well as increased mortality in patients. This study from Germany aimed to characterize the effects of high glucose on epidermal keratinocytes, the cells of the outermost layer of the skin and a key cell type for wound healing. Furthermore, it examined if a small molecule, called KdPT, can protect keratinocytes from glucose-induced stress and toxicity. The authors investigated various functions of keratinocytes under high-glucose conditions with or without KdPT in cell culture models as well as in skin biopsies from healthy subjects. High glucose reduced cell proliferation and viability (meaning it caused a decrease in the number of cells, and a decrease in the number of healthy cells), and migration (cellular movement) of keratinocytes. It also altered the cell size and elasticity. Parallel to these changes, increased amounts of reactive oxygen species, which are toxic to cells, as well as intracellular stress were observed. However, KdPT reduced some of these negative effects of high glucose. The authors' findings highlight a novel effect of KdPT, which could be used to develop new treatments for diabetic skin ulcers.

Original languageEnglish (US)
Pages (from-to)e108-e139
JournalThe British journal of dermatology
Volume180
Issue number4
DOIs
StatePublished - Apr 1 2019

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Keratinocytes
Glucose
Skin Ulcer
Foot Ulcer
Skin
Poisons
Elasticity
Diabetes Complications
Cell Size
Wound Healing
Ulcer
Cell Movement
Germany
Reactive Oxygen Species
Cell Survival
Healthy Volunteers
Cell Culture Techniques
Cell Count
Cell Proliferation
Delivery of Health Care

ASJC Scopus subject areas

  • Dermatology

Cite this

Gkogkolou, P., Sarna, M., Sarna, T., Paus, R., Luger, T. A., & Böhm, M. (2019). Abstracts. The British journal of dermatology, 180(4), e108-e139. https://doi.org/10.1111/bjd.17650

Abstracts. / Gkogkolou, P.; Sarna, M.; Sarna, T.; Paus, Ralf; Luger, T. A.; Böhm, M.

In: The British journal of dermatology, Vol. 180, No. 4, 01.04.2019, p. e108-e139.

Research output: Contribution to journalArticle

Gkogkolou, P, Sarna, M, Sarna, T, Paus, R, Luger, TA & Böhm, M 2019, 'Abstracts', The British journal of dermatology, vol. 180, no. 4, pp. e108-e139. https://doi.org/10.1111/bjd.17650
Gkogkolou P, Sarna M, Sarna T, Paus R, Luger TA, Böhm M. Abstracts. The British journal of dermatology. 2019 Apr 1;180(4):e108-e139. https://doi.org/10.1111/bjd.17650
Gkogkolou, P. ; Sarna, M. ; Sarna, T. ; Paus, Ralf ; Luger, T. A. ; Böhm, M. / Abstracts. In: The British journal of dermatology. 2019 ; Vol. 180, No. 4. pp. e108-e139.
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