Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle

Antonio Barrientos, Jordi Casademont, Agnès Rötig, Òscar Miró, Álvaro Urbano-Márquez, Pierre Rustin, Francesc Cardellach

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

We investigated the relationship between age and respiratory chain function of skeletal muscle mitochondria in 132 control individuals (15 to 95 years old). Muscle mitochondria were studied polarographically and spectrophotometrically. By regression analysis, we found a significant inverse correlation between age and oxygen uptake linked to substrate oxidation (succinate, glutamate-malate or ascorbate-TMPD). However, this significance disappeared after including physical activity and tobacco consumption as confounding variables in a multivariate statistical analysis. Similarly, the activity of respiratory chain complexes individually measured did not decline with age. It therefore appears that respiratory chain activity in human skeletal muscle mitochondria is substantially undamaged during the aging process.

Original languageEnglish
Pages (from-to)536-539
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume229
Issue number2
DOIs
StatePublished - Dec 13 1996
Externally publishedYes

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Muscle Mitochondrion
Mitochondria
Electron Transport
Muscle
Skeletal Muscle
Aging of materials
Confounding Factors (Epidemiology)
Tobacco
Tobacco Use
Succinic Acid
Human Activities
Regression analysis
Glutamic Acid
Statistical methods
Multivariate Analysis
Regression Analysis
Oxygen
Oxidation
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle. / Barrientos, Antonio; Casademont, Jordi; Rötig, Agnès; Miró, Òscar; Urbano-Márquez, Álvaro; Rustin, Pierre; Cardellach, Francesc.

In: Biochemical and Biophysical Research Communications, Vol. 229, No. 2, 13.12.1996, p. 536-539.

Research output: Contribution to journalArticle

Barrientos, Antonio ; Casademont, Jordi ; Rötig, Agnès ; Miró, Òscar ; Urbano-Márquez, Álvaro ; Rustin, Pierre ; Cardellach, Francesc. / Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle. In: Biochemical and Biophysical Research Communications. 1996 ; Vol. 229, No. 2. pp. 536-539.
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