Absence of functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab-/- mice

Gabrielle T. Belz, Haiyan Liu, Samita Andreansky, Peter C. Doherty, Philip G. Stevenson

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The murine gammaherpesvirus-68 kills I-Ab-/- mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-Ab-/- mice and I-Ab+/+ controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalJournal of General Virology
Volume84
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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