Abnormalities of the hypothalamo-pituitary-thyroid axis in the pro-opiomelanocortin deficient mouse

Niamh M. Martin, Caroline J. Small, Arshia Sajedi, Xiao H. Liao, Roy E. Weiss, James V. Gardiner, Mohammad A. Ghatei, Stephen R. Bloom

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The melanocortin system is an important regulator of body weight and the hypothalamo-pituitary-thyroid (HPT) axis. The pro-opiomelanocortin (POMC)-null mouse, deficient in all POMC-derived peptides, including alpha-melanocyte stimulating hormone (α-MSH), has an obese phenotype. We studied the HPT axis of POMC-null mice, which has not been previously investigated. Because α-MSH has a stimulatory effect on the HPT axis, we hypothesised that these mice would have a down-regulated thyroid axis, consistent with a recent study of POMC-null humans. The activity of the HPT axis was studied by collecting blood, pituitaries and hypothalami from ad libitum fed, adult POMC-null, heterozygous and wild-type mice. POMC-null mice had significantly elevated plasma total T4 (TT4) and free T3 (fT 3) with reduced plasma thyroid stimulating hormone (TSH), pituitary TSH content and hypothalamic thyrotrophin stimulating hormone (TRH) content compared to wild-type mice. No significant differences between heterozygous and wild-type mice were observed. POMC-null mice have an abnormal HPT axis, which may contribute to their hyperphagia and obesity. These abnormalities are in contrast to those observed in POMC-null humans. These findings support a role for the melanocortin system in the regulation of the HPT axis.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalRegulatory Peptides
Volume122
Issue number3
DOIs
StatePublished - Nov 15 2004
Externally publishedYes

Keywords

  • Obesity
  • Pro-opiomelanocortin (POMC)
  • Thyroid hormones
  • Thyroid stimulating hormone (TSH)
  • Thyrotrophin releasing hormone (TRH)

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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    Martin, N. M., Small, C. J., Sajedi, A., Liao, X. H., Weiss, R. E., Gardiner, J. V., Ghatei, M. A., & Bloom, S. R. (2004). Abnormalities of the hypothalamo-pituitary-thyroid axis in the pro-opiomelanocortin deficient mouse. Regulatory Peptides, 122(3), 169-172. https://doi.org/10.1016/j.regpep.2004.06.012