Abnormalities of antioxidant metabolism in a case of Friedreich's disease

Wendell Helveston, Jean E. Cibula, Russell Hurd, Basim M. Uthman, B. J. Wilder

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We report a patient with Friedreich's disease (FD) who exhibited abnormalities of antioxidant metabolism, including decreased levels of glutathione peroxidase, glutathione reductase, and selenium, and an increased lipid peroxide index. These abnormalities became normal after treatment with N-acetylcysteine, selenium, and low-dose vitamin E therapy. Treatment was associated with a decreased rate of clinical decline. FD is a neurodegenerative disorder that may be related to disturbed antioxidant metabolism: the disorder may be treatable with antioxidant compounds.

Original languageEnglish (US)
Pages (from-to)271-275
Number of pages5
JournalClinical neuropharmacology
Issue number3
StatePublished - 1996
Externally publishedYes


  • Antioxidant
  • Ataxia
  • Freidreich's
  • N-Acetylcysteine

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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