Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases

Errol B. De Souza, Garth Bissette, Peter J. Whitehouse, Richard E. Powers, Donald L. Price, Wylie Vale, Charles B. Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter


The pathologies occumng in various neurodegenerative disorders are associated with dysfunction and death of neurons in a variety of cell populations, including cholinergic, monoaminergic, and peptidergic systems. Corticotropin-releasing factor (CRF) has been demonstrated to have a broad distribution in the central nervous system (CNS) and to produce a wide spectrum of autonomic, electrophysiologic, and behavioral effects characteristic of a neurotransmitter in the CNS (see various chapters). Recent clinical data suggest that CRF may be of relevance in endocrine, psychiatric, and neurologic illnesses. In this chapter, we summarize some of the data from our recent studies examining changes in pre- and postsynaptic markers for CRF in various brain regions in a variety of neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s Disease (PD), progressive supranuclear palsy (PSP), and Huntington’s Disease (HD).

Original languageEnglish (US)
Title of host publicationCorticotropin-Releasing Factor
Subtitle of host publicationBasic and Clinical Studies of a Neuropeptide
PublisherCRC Press
Number of pages15
ISBN (Electronic)9781351079389
ISBN (Print)0849345502, 9781315891835
StatePublished - Jan 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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