Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases

Errol B. De Souza, Garth Bissette, Peter J. Whitehouse, Richard E. Powers, Donald L. Price, Wylie Vale, Charles Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pathologies occumng in various neurodegenerative disorders are associated with dysfunction and death of neurons in a variety of cell populations, including cholinergic, monoaminergic, and peptidergic systems. Corticotropin-releasing factor (CRF) has been demonstrated to have a broad distribution in the central nervous system (CNS) and to produce a wide spectrum of autonomic, electrophysiologic, and behavioral effects characteristic of a neurotransmitter in the CNS (see various chapters). Recent clinical data suggest that CRF may be of relevance in endocrine, psychiatric, and neurologic illnesses. In this chapter, we summarize some of the data from our recent studies examining changes in pre- and postsynaptic markers for CRF in various brain regions in a variety of neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s Disease (PD), progressive supranuclear palsy (PSP), and Huntington’s Disease (HD).

LanguageEnglish (US)
Title of host publicationCorticotropin-Releasing Factor
Subtitle of host publicationBasic and Clinical Studies of a Neuropeptide
PublisherCRC Press
Pages335-349
Number of pages15
ISBN (Electronic)9781351079389
ISBN (Print)0849345502, 9781315891835
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Neurodegenerative Diseases
Central Nervous System
Progressive Supranuclear Palsy
Huntington Disease
Cholinergic Agents
Nervous System
Neurotransmitter Agents
Parkinson Disease
Psychiatry
Alzheimer Disease
Pathology
Neurons
Brain
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

De Souza, E. B., Bissette, G., Whitehouse, P. J., Powers, R. E., Price, D. L., Vale, W., & Nemeroff, C. (2018). Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases. In Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide (pp. 335-349). CRC Press. https://doi.org/10.1201/9781351070935

Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases. / De Souza, Errol B.; Bissette, Garth; Whitehouse, Peter J.; Powers, Richard E.; Price, Donald L.; Vale, Wylie; Nemeroff, Charles.

Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide. CRC Press, 2018. p. 335-349.

Research output: Chapter in Book/Report/Conference proceedingChapter

De Souza, EB, Bissette, G, Whitehouse, PJ, Powers, RE, Price, DL, Vale, W & Nemeroff, C 2018, Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases. in Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide. CRC Press, pp. 335-349. https://doi.org/10.1201/9781351070935
De Souza EB, Bissette G, Whitehouse PJ, Powers RE, Price DL, Vale W et al. Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases. In Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide. CRC Press. 2018. p. 335-349 https://doi.org/10.1201/9781351070935
De Souza, Errol B. ; Bissette, Garth ; Whitehouse, Peter J. ; Powers, Richard E. ; Price, Donald L. ; Vale, Wylie ; Nemeroff, Charles. / Abnormalities in corticotropin-releasing factor (CRF) in neurodegenerative diseases. Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide. CRC Press, 2018. pp. 335-349
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