Abnormal Sodium Regulation in Rats Following Chronic Intermittent Exposure to Carbon Tetrachloride

Ulrich F. Michael, Robert L. Barenberg, Donald Levi, Victoriano Pardo, Rafaelita Chavez, Solomon Papper

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Rats with nodular cirrhosis due to CCl4 intoxication showed a higher net positive sodium balance than their age-matched controls during three metabolic balance studies, done 10, 16, and 40 weeks after initial exposure to CCl4. Renal hemodynamics and Uosm max were not different between both groups. The data suggest that intermittent periods of sodium retention precede the development of ascites in rats with CCl4-innduced cirrhosis of the liver and that these changes occur in the presence of intact glomerular and tubular renal function.

Original languageEnglish (US)
Pages (from-to)796-799
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume138
Issue number3
DOIs
StatePublished - Dec 1971

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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