Abnormal RNA metabolism in spinal motor neurons in the wobbler mouse

T. Murakami, F. L. Mastaglia, D. M A Mann, Walter G Bradley

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

RNA metabolism was studied in anterior horn neurons in wobbler mice. In the wobbler mice, RNA content was reduced in histologically normal neurons but not consistently reduced in vacuolated neurons, as compared with normal littermates. Nuclear and nucleolar incorporation of [5-3H]uridine was reduced both in vacuolated and in histologically normal neurons of wobbler mice, while cytoplasmic counts were higher in histologically normal neurons of wobbler mice than in vacuolated neurons or the neurons of normal littermates. These findings point to an abnormality of RNA synthesis which precedes the earliest morphological changes seen in nerve cells with the light microscope. Nuclear [5-3H]uridine uptake was reduced both in small and in large neurons, a finding suggesting that the metabolic abnormality is probably not confined to α-motorneurons.

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalMuscle and Nerve
Volume4
Issue number5
StatePublished - Jan 1 1981
Externally publishedYes

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Motor Neurons
RNA
Neurons
Uridine
Anterior Horn Cells
Light

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Murakami, T., Mastaglia, F. L., Mann, D. M. A., & Bradley, W. G. (1981). Abnormal RNA metabolism in spinal motor neurons in the wobbler mouse. Muscle and Nerve, 4(5), 407-412.

Abnormal RNA metabolism in spinal motor neurons in the wobbler mouse. / Murakami, T.; Mastaglia, F. L.; Mann, D. M A; Bradley, Walter G.

In: Muscle and Nerve, Vol. 4, No. 5, 01.01.1981, p. 407-412.

Research output: Contribution to journalArticle

Murakami, T, Mastaglia, FL, Mann, DMA & Bradley, WG 1981, 'Abnormal RNA metabolism in spinal motor neurons in the wobbler mouse', Muscle and Nerve, vol. 4, no. 5, pp. 407-412.
Murakami T, Mastaglia FL, Mann DMA, Bradley WG. Abnormal RNA metabolism in spinal motor neurons in the wobbler mouse. Muscle and Nerve. 1981 Jan 1;4(5):407-412.
Murakami, T. ; Mastaglia, F. L. ; Mann, D. M A ; Bradley, Walter G. / Abnormal RNA metabolism in spinal motor neurons in the wobbler mouse. In: Muscle and Nerve. 1981 ; Vol. 4, No. 5. pp. 407-412.
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