Abnormal pituitary-adrenocortical response in early HIV-1 infection

Mahendra Kumar, Adarsh Kumar, R. Morgan, Jose Szapocznik, C. Eisdorfer

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The corticotropin-adrenocortical response to cold pressor challenge was investigated in a study of human immunodeficiency virus (HIV) infection. Data obtained from 16 HIV-1-positive and 28 HIV-1-negative subjects are presented in this report. After the insertion of a venicatheter and following 30 min of rest, the subjects immersed one of their hands in an ice-water mixture for 2 min, and serial blood samples were obtained for the determination of ACTH and cortisol levels. The results show a significant blunting in the ACTH response and marginally lower levels of cortisol, over all time points, in HIV-1-positive subjects compared to that in HIV-1-negative subjects.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume6
Issue number1
StatePublished - Jan 1 1993

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Virus Diseases
HIV-1
Adrenocorticotropic Hormone
Hydrocortisone
Ice
Hand
HIV
Water

ASJC Scopus subject areas

  • Virology
  • Immunology and Allergy

Cite this

Abnormal pituitary-adrenocortical response in early HIV-1 infection. / Kumar, Mahendra; Kumar, Adarsh; Morgan, R.; Szapocznik, Jose; Eisdorfer, C.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 6, No. 1, 01.01.1993, p. 61-65.

Research output: Contribution to journalArticle

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