Abnormal pituitary-adrenocortical response in early hiv-1 infection

Mahendra Kumar, Adarsh M. Kumar, Robert Morgan, Jose Szapocznik, Carl Eisdorfer

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The corticotropin-adrenocortical response to cold pressor challenge was investigated in a study of human immunodeficiency virus (HIV) infection. Data obtained from 16 HIV-1-positive and 28 HIV-1-negative subjects are presented in this report. After the insertion of a venicatheter and following 30 min of rest, the subjects immersed one of their hands in an ice-water mixture for 2 min, and serial blood samples were obtained for the determination of ACTH and cortisol levels. The results show a significant blunting in the ACTH response and marginally lower levels of cortisol, over all time points, in HIV-1-positive subjects compared to that in HIV-1-negative subjects.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume6
Issue number1
StatePublished - Jan 1993

Keywords

  • ACTH
  • Cold pressor test
  • Cortisol
  • Endocrine
  • HIV
  • Pituitary-Adrenocortical axis
  • Stress

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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