Abnormal ocular motor control in huntington’s disease

R. John Leigh, Steven A. Newma, Susan E. Folstein, Adrian G. Lasker, Barbara A. Jensen

Research output: Contribution to journalArticlepeer-review

175 Scopus citations


We studied eye movements in 50 patients with Huntington's disease. Fixation was impaired in 73% of patients; such individuals had difficulty in suppressing saccades toward novel visual stimuli. Impaired initiation of saccades was manifest by increased reaction time (89%) and inability to make a saccade without head movements (89%) or blink (35%). Saccades and quick phases of nystagmus were slowed in 62%. Smooth pursuit was abnormal in 60%, and vergence in 33%. The vestibulo-ocular reflex and the ability to hold eccentric gaze were preserved even late in the disease.

Original languageEnglish (US)
Pages (from-to)1268-1275
Number of pages8
Issue number10
StatePublished - Oct 1983
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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