Abstract
We studied eye movements in 50 patients with Huntington's disease. Fixation was impaired in 73% of patients; such individuals had difficulty in suppressing saccades toward novel visual stimuli. Impaired initiation of saccades was manifest by increased reaction time (89%) and inability to make a saccade without head movements (89%) or blink (35%). Saccades and quick phases of nystagmus were slowed in 62%. Smooth pursuit was abnormal in 60%, and vergence in 33%. The vestibulo-ocular reflex and the ability to hold eccentric gaze were preserved even late in the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1268-1275 |
| Number of pages | 8 |
| Journal | Neurology |
| Volume | 33 |
| Issue number | 10 |
| State | Published - Dec 27 1983 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Abnormal ocular motor control in Huntington's disease. / Leigh, R. J.; Newman, S. A.; Folstein, S. E.; Lasker, A. G.; Jensen, B. A.
In: Neurology, Vol. 33, No. 10, 27.12.1983, p. 1268-1275.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abnormal ocular motor control in Huntington's disease
AU - Leigh, R. J.
AU - Newman, S. A.
AU - Folstein, S. E.
AU - Lasker, A. G.
AU - Jensen, B. A.
PY - 1983/12/27
Y1 - 1983/12/27
N2 - We studied eye movements in 50 patients with Huntington's disease. Fixation was impaired in 73% of patients; such individuals had difficulty in suppressing saccades toward novel visual stimuli. Impaired initiation of saccades was manifest by increased reaction time (89%) and inability to make a saccade without head movements (89%) or blink (35%). Saccades and quick phases of nystagmus were slowed in 62%. Smooth pursuit was abnormal in 60%, and vergence in 33%. The vestibulo-ocular reflex and the ability to hold eccentric gaze were preserved even late in the disease.
AB - We studied eye movements in 50 patients with Huntington's disease. Fixation was impaired in 73% of patients; such individuals had difficulty in suppressing saccades toward novel visual stimuli. Impaired initiation of saccades was manifest by increased reaction time (89%) and inability to make a saccade without head movements (89%) or blink (35%). Saccades and quick phases of nystagmus were slowed in 62%. Smooth pursuit was abnormal in 60%, and vergence in 33%. The vestibulo-ocular reflex and the ability to hold eccentric gaze were preserved even late in the disease.
UR - http://www.scopus.com/inward/record.url?scp=0020557409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020557409&partnerID=8YFLogxK
M3 - Article
C2 - 6225033
AN - SCOPUS:0020557409
VL - 33
SP - 1268
EP - 1275
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 10
ER -