Abnormal ocular motor control in Huntington's disease

R. J. Leigh, S. A. Newman, S. E. Folstein, A. G. Lasker, B. A. Jensen

Research output: Contribution to journalArticle

165 Scopus citations


We studied eye movements in 50 patients with Huntington's disease. Fixation was impaired in 73% of patients; such individuals had difficulty in suppressing saccades toward novel visual stimuli. Impaired initiation of saccades was manifest by increased reaction time (89%) and inability to make a saccade without head movements (89%) or blink (35%). Saccades and quick phases of nystagmus were slowed in 62%. Smooth pursuit was abnormal in 60%, and vergence in 33%. The vestibulo-ocular reflex and the ability to hold eccentric gaze were preserved even late in the disease.

Original languageEnglish
Pages (from-to)1268-1275
Number of pages8
Issue number10
StatePublished - Dec 27 1983


ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Leigh, R. J., Newman, S. A., Folstein, S. E., Lasker, A. G., & Jensen, B. A. (1983). Abnormal ocular motor control in Huntington's disease. Neurology, 33(10), 1268-1275.