Abnormal development of B cells and B cell progenitors in autoimmune (NZB × NZW)F1 mice

Richard L. Riley, Mark G. Kruger, Esther A. Riley

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The (NZB × NZW)F1 (BWF1) autoimmune strain displays reduced numbers of both cμ+ pre-B cells and Ly5(220)+ B cell progenitors in the bone marrow. The loss of these B cell precursor populations in the bone marrow increases with age. In contrast, the bone marrow of BWF1 mice possesses sIg+ B cells comparable in both number and surface phenotype to that observed in conventional strains. Analysis of the surface densities of both sIg and Ly5(220) antigens indicates that BWF1 bone marrow B cells comprise a heterogeneous population of both immature and mature B cells. In addition, BWF1 bone marrow still possessed progenitor cells capable of yielding newly generated B cell precursors and B cells in vitro. The diminished levels of intermediate B cell progenitors observed in BWF1 bone marrow may reflect abnormal regulation of B lineage differentiation during the life span of this autoimmune strain.

Original languageEnglish (US)
Pages (from-to)372-385
Number of pages14
JournalClinical Immunology and Immunopathology
Issue number3
StatePublished - Mar 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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