Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder

Willa Voorhies, Dina R. Dajani, Shruti G. Vij, Sahana Shankar, Turel Ozerk Turan, Lucina Q Uddin

Research output: Contribution to journalArticle

Abstract

Development of inhibitory control is a core component of executive function processes and a key aspect of healthy development. Children with autism spectrum disorder (ASD) show impairments in performance on inhibitory control tasks. Nevertheless, the research on the neural correlates of these impairments is inconclusive. Here, we explore the integrity of inhibitory control networks in children with ASD and typically developing (TD) children using resting state functional Magnetic Resonance Imagaing (MRI). In a large multisite sample, we find evidence for significantly greater functional connectivity (FC) of the right inferior frontal junction (rIFJ) with the posterior cingulate gyrus, and left and right frontal poles in children with ASD compared with TD children. Additionally, TD children show greater FC of rIFJ with the superior parietal lobule (SPL) compared with children with ASD. Furthermore, although higher rIFJ-SPL and rIFJ-IPL FC was related to better inhibitory control behaviors in both ASD and TD children, rIFJ-dACC FC was only associated with inhibitory control behaviors in TD children. These results provide preliminary evidence of differences in intrinsic functional networks supporting inhibitory control in children with ASD, and provide a basis for further exploration of the development of inhibitory control in children with the disorder. Lay Summary: Inhibitory control is an important process in healthy cognitive development. Behavioral studies suggest that inhibitory control is impaired in autism spectrum disorder (ASD). However, research examining the neural correlates underlying inhibitory control differences in children with ASD is inconclusive. This study reveals differences in functional connectivity of brain networks important for inhibitory control in children with ASD compared with typically developing children. Furthermore, it relates brain network differences to parent-reported inhibitory control behaviors in children with ASD. These findings provide support for the hypothesis that differences in brain connectivity may underlie observable behavioral deficits in inhibitory control in children with the disorder. Autism Res 2018.

LanguageEnglish (US)
JournalAutism Research
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Behavior Control
Parietal Lobe
Autism Spectrum Disorder
Brain
Gyrus Cinguli
Executive Function
Child Behavior
Autistic Disorder
Research
Magnetic Resonance Spectroscopy

Keywords

  • autism spectrum disorder
  • brain development
  • functional connectivity
  • inhibitory control
  • resting-state fMRI

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Genetics(clinical)

Cite this

Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder. / Voorhies, Willa; Dajani, Dina R.; Vij, Shruti G.; Shankar, Sahana; Turan, Turel Ozerk; Uddin, Lucina Q.

In: Autism Research, 01.01.2018.

Research output: Contribution to journalArticle

Voorhies, Willa ; Dajani, Dina R. ; Vij, Shruti G. ; Shankar, Sahana ; Turan, Turel Ozerk ; Uddin, Lucina Q. / Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder. In: Autism Research. 2018.
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