Aberrant Epigenetic Gene Regulation in Lymphoid Malignancies

Kristen H. Taylor, Aaron Briley, Zheng Wang, Jianlin Cheng, Huidong Shi, Charles W. Caldwell

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In lymphoid malignancies, aberrant epigenetic mechanisms such as DNA methylation and histone modifications influence chromatin architecture and can result in altered gene expression. These alterations commonly affect genes that play important roles in the cell cycle, apoptosis, and DNA repair in non-Hodgkin lymphoma (NHL). The ability to identify epigenetic modifications to these important genes has increased exponentially due to advances in technology. As a result, there are well-defined, gene-specific epigenetic aberrations associated with NHL comprising follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and diffuse large B-cell lymphoma (DLBCL). The identification of these genes is important because they may be used as biomarkers for prognosis, diagnosis and in developing improved treatment strategies. Also important, in the control of gene expression, is the packaging of DNA within the nucleus of a cell. This packaging can be distorted by epigenetic alterations and may alter the accessibility of certain regions of the genome in cancer cells. This review discusses the impact of known epigenetic aberration on the regulation of gene expression in NHL and provides insight into the spatial conformation of the genome (DNA packaging) in acute lymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)38-47
Number of pages10
JournalSeminars in Hematology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Epigenomics
DNA Packaging
Non-Hodgkin's Lymphoma
Genes
Neoplasms
Histone Code
Genome
Gene Expression
Mantle-Cell Lymphoma
Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
Gene Expression Regulation
Product Packaging
DNA Methylation
B-Cell Chronic Lymphocytic Leukemia
Cell Nucleus
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA Repair
Chromatin
Cell Cycle

ASJC Scopus subject areas

  • Hematology

Cite this

Aberrant Epigenetic Gene Regulation in Lymphoid Malignancies. / Taylor, Kristen H.; Briley, Aaron; Wang, Zheng; Cheng, Jianlin; Shi, Huidong; Caldwell, Charles W.

In: Seminars in Hematology, Vol. 50, No. 1, 01.01.2013, p. 38-47.

Research output: Contribution to journalArticle

Taylor, KH, Briley, A, Wang, Z, Cheng, J, Shi, H & Caldwell, CW 2013, 'Aberrant Epigenetic Gene Regulation in Lymphoid Malignancies', Seminars in Hematology, vol. 50, no. 1, pp. 38-47. https://doi.org/10.1053/j.seminhematol.2013.01.003
Taylor, Kristen H. ; Briley, Aaron ; Wang, Zheng ; Cheng, Jianlin ; Shi, Huidong ; Caldwell, Charles W. / Aberrant Epigenetic Gene Regulation in Lymphoid Malignancies. In: Seminars in Hematology. 2013 ; Vol. 50, No. 1. pp. 38-47.
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