Abdominal Wall Transplantation: Surgical and Immunologic Aspects

Gennaro Selvaggi, D. M. Levi, R. Cipriani, R. Sgarzani, A. D. Pinna, A. G. Tzakis

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Abdominal wall transplantation is a type of composite tissue allograft that can be utilized to reconstitute the abdominal domain of patients undergoing intestinal transplantation. We have presented herein combined experience and long-term follow-up results of a series of abdominal wall transplants performed at 2 institutions. A total of 15 abdominal wall transplants from cadaveric donors were performed in 14 patients at the end of intestinal transplant surgery or, in 2 cases, a few days after the primary intestinal transplant. The vascular supply was through the inferior epigastric vessels, from the iliac vessels in 12 cases and via a microsurgical technique in 3 cases. Immunosuppression consisted of induction with alemtuzumab and maintenance treatment with tacrolimus monotherapy. Two grafts lost to vascular thrombosis were removed. Five patients are still alive, although all deaths were unrelated to the abdominal wall transplant. There were 3 episodes of abdominal wall graft rejection, treated with steroids; the abdominal wall graft and the intestinal grafts experienced rejection independent from each other. In summary, abdominal wall transplantation is a feasible technique for recipients of intestinal or multivisceral transplants, when the closure of the abdominal cavity by primary intention is technically impossible.

Original languageEnglish
Pages (from-to)521-522
Number of pages2
JournalTransplantation Proceedings
Volume41
Issue number2
DOIs
StatePublished - Mar 1 2009

Fingerprint

Abdominal Wall
Transplantation
Transplants
Graft Rejection
Blood Vessels
Composite Tissue Allografts
Abdominal Cavity
Tacrolimus
Immunosuppression
Thrombosis
Steroids
Tissue Donors

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Abdominal Wall Transplantation : Surgical and Immunologic Aspects. / Selvaggi, Gennaro; Levi, D. M.; Cipriani, R.; Sgarzani, R.; Pinna, A. D.; Tzakis, A. G.

In: Transplantation Proceedings, Vol. 41, No. 2, 01.03.2009, p. 521-522.

Research output: Contribution to journalArticle

Selvaggi, G, Levi, DM, Cipriani, R, Sgarzani, R, Pinna, AD & Tzakis, AG 2009, 'Abdominal Wall Transplantation: Surgical and Immunologic Aspects', Transplantation Proceedings, vol. 41, no. 2, pp. 521-522. https://doi.org/10.1016/j.transproceed.2009.01.020
Selvaggi, Gennaro ; Levi, D. M. ; Cipriani, R. ; Sgarzani, R. ; Pinna, A. D. ; Tzakis, A. G. / Abdominal Wall Transplantation : Surgical and Immunologic Aspects. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 2. pp. 521-522.
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