ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity

Solange Landreville, Olga A. Agapova, Zachary T. Kneass, Christian Salesse, J. William Harbour

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Metastasis of tumor cells to distant organs is the leading cause of death in melanoma. Yet, the mechanisms of metastasis remain poorly understood. One key question is whether all cells in a primary tumor are equally likely to metastasize or whether subpopulations of cells preferentially give rise to metastases. Here, we identified a subpopulation of uveal melanoma cells expressing the multidrug resistance transporter ABCB1 that are highly metastatic compared to ABCB1- bulk tumor cells. ABCB1+ cells also exhibited enhanced clonogenicity, anchorage-independent growth, tumorigenicity and mitochondrial activity compared to ABCB1- cells. A375 cutaneous melanoma cells contained a similar subpopulation of highly metastatic ABCB1+ cells. These findings suggest that some uveal melanoma cells have greater potential for metastasis than others and that a better understanding of such cells may be necessary for more successful therapies for metastatic melanoma.

Original languageEnglish (US)
Pages (from-to)430-437
Number of pages8
JournalPigment Cell and Melanoma Research
Volume24
Issue number3
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Keywords

  • ABCB1
  • Immunodeficient mouse model
  • Metastasis
  • Mitochondrial respiration
  • Uveal melanoma

ASJC Scopus subject areas

  • Dermatology
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)

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