Abstract
The aim of this study was to identify the best subset of neuropsychological tests for prediction of several different aspects of functioning in a large (n = 236) sample of older people with schizophrenia. While the validity of abbreviated assessment methods has been examined before, there has never been a comparative study of the prediction of different elements of cognitive impairment, real-world outcomes, and performance-based measures of functional capacity. Scores on 10 different tests from a neuropsychological assessment battery were used to predict global neuropsychological (NP) performance (indexed with averaged scores or calculated general deficit scores), performance-based indices of everyday-living skills and social competence, and case-manager ratings of real-world functioning. Forward entry stepwise regression analyses were used to identify the best predictors for each of the outcomes measures. Then, the analyses were adjusted for estimated premorbid IQ, which reduced the magnitude, but not the structure, of the correlations. Substantial amounts (over 70%) of the variance in overall NP performance were accounted for by a limited number of NP tests. Considerable variance in measures of functional capacity was also accounted for by a limited number of tests. Different tests constituted the best predictor set for each outcome measure. A substantial proportion of the variance in several different NP and functional outcomes can be accounted for by a small number of NP tests that can be completed in a few minutes, although there is considerable unexplained variance. However, the abbreviated assessments that best predict different outcomes vary across outcomes. Future studies should determine whether responses to pharmacological and remediation treatments can be captured with brief assessments as well.
| Original language | English |
|---|---|
| Pages (from-to) | 462-471 |
| Number of pages | 10 |
| Journal | Journal of Clinical and Experimental Neuropsychology |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1 2009 |
| Externally published | Yes |
Fingerprint
Keywords
- Abbreviated assessments
- Disability
- Functional capacity
- Neuropsychological assessment
- Schizophrenia
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Clinical Psychology
Cite this
Abbreviated neuropsychological assessment in schizophrenia : Prediction of different aspects of outcome. / Harvey, Philip D; Keefe, Richard S E; Patterson, Thomas L.; Heaton, Robert K.; Bowie, Christopher R.
In: Journal of Clinical and Experimental Neuropsychology, Vol. 31, No. 4, 01.05.2009, p. 462-471.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abbreviated neuropsychological assessment in schizophrenia
T2 - Prediction of different aspects of outcome
AU - Harvey, Philip D
AU - Keefe, Richard S E
AU - Patterson, Thomas L.
AU - Heaton, Robert K.
AU - Bowie, Christopher R.
PY - 2009/5/1
Y1 - 2009/5/1
N2 - The aim of this study was to identify the best subset of neuropsychological tests for prediction of several different aspects of functioning in a large (n = 236) sample of older people with schizophrenia. While the validity of abbreviated assessment methods has been examined before, there has never been a comparative study of the prediction of different elements of cognitive impairment, real-world outcomes, and performance-based measures of functional capacity. Scores on 10 different tests from a neuropsychological assessment battery were used to predict global neuropsychological (NP) performance (indexed with averaged scores or calculated general deficit scores), performance-based indices of everyday-living skills and social competence, and case-manager ratings of real-world functioning. Forward entry stepwise regression analyses were used to identify the best predictors for each of the outcomes measures. Then, the analyses were adjusted for estimated premorbid IQ, which reduced the magnitude, but not the structure, of the correlations. Substantial amounts (over 70%) of the variance in overall NP performance were accounted for by a limited number of NP tests. Considerable variance in measures of functional capacity was also accounted for by a limited number of tests. Different tests constituted the best predictor set for each outcome measure. A substantial proportion of the variance in several different NP and functional outcomes can be accounted for by a small number of NP tests that can be completed in a few minutes, although there is considerable unexplained variance. However, the abbreviated assessments that best predict different outcomes vary across outcomes. Future studies should determine whether responses to pharmacological and remediation treatments can be captured with brief assessments as well.
AB - The aim of this study was to identify the best subset of neuropsychological tests for prediction of several different aspects of functioning in a large (n = 236) sample of older people with schizophrenia. While the validity of abbreviated assessment methods has been examined before, there has never been a comparative study of the prediction of different elements of cognitive impairment, real-world outcomes, and performance-based measures of functional capacity. Scores on 10 different tests from a neuropsychological assessment battery were used to predict global neuropsychological (NP) performance (indexed with averaged scores or calculated general deficit scores), performance-based indices of everyday-living skills and social competence, and case-manager ratings of real-world functioning. Forward entry stepwise regression analyses were used to identify the best predictors for each of the outcomes measures. Then, the analyses were adjusted for estimated premorbid IQ, which reduced the magnitude, but not the structure, of the correlations. Substantial amounts (over 70%) of the variance in overall NP performance were accounted for by a limited number of NP tests. Considerable variance in measures of functional capacity was also accounted for by a limited number of tests. Different tests constituted the best predictor set for each outcome measure. A substantial proportion of the variance in several different NP and functional outcomes can be accounted for by a small number of NP tests that can be completed in a few minutes, although there is considerable unexplained variance. However, the abbreviated assessments that best predict different outcomes vary across outcomes. Future studies should determine whether responses to pharmacological and remediation treatments can be captured with brief assessments as well.
KW - Abbreviated assessments
KW - Disability
KW - Functional capacity
KW - Neuropsychological assessment
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=67649910511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649910511&partnerID=8YFLogxK
U2 - 10.1080/13803390802251386
DO - 10.1080/13803390802251386
M3 - Article
C2 - 18720182
AN - SCOPUS:67649910511
VL - 31
SP - 462
EP - 471
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
SN - 1380-3395
IS - 4
ER -