A versatile synthesis of substituted tetrahydropyridines

S. C. Schurer, S. Blechert

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

A short and efficient synthesis of highly substituted tetrahydropyridines is achieved by a combination of enyne cross metathesis and aza-Diels-Alder reaction under high pressure. The reaction sequence shows atom economy and is compatible with a variety of functionalities being introduced by three building blocks: a monosubstituted alkyne, a terminal alkene, and an imine.

Original languageEnglish (US)
Pages (from-to)1877-1880
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number10
DOIs
StatePublished - Mar 5 1999
Externally publishedYes

Keywords

  • Diels-Alder reactions
  • Metathesis
  • Piperidines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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