A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-L2)

Yao Shan Fan; Jacob M. Rowe; Paola Dal Cin; Avery A. Sandberg

doi:10.1016/0165-4608(88)90226-9

A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-L2)

Yao Shan Fan, Jacob M. Rowe, Paola Dal Cin, Avery A. Sandberg

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We here report a t(9;11)(p11;q23) as the only abnormality in the affected cells of a 20-year-old male with acute lymphoblastic leukemia (L2) of T-cell origin. One hundred six patients with acute leukemia and involvement of band 11q23 were reviewed. Young age, hyperleukocytosis, and poor prognosis characterized almost all the cases in the acute leukemias with the 11q23 translocation, despite involvement of different recipient chromosomes and different morphologic and immunologic phenotypes.

Original language	English (US)
Pages (from-to)	263-269
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(88)90226-9
State	Published - Apr 1988
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-L2)",

abstract = "We here report a t(9;11)(p11;q23) as the only abnormality in the affected cells of a 20-year-old male with acute lymphoblastic leukemia (L2) of T-cell origin. One hundred six patients with acute leukemia and involvement of band 11q23 were reviewed. Young age, hyperleukocytosis, and poor prognosis characterized almost all the cases in the acute leukemias with the 11q23 translocation, despite involvement of different recipient chromosomes and different morphologic and immunologic phenotypes.",

author = "Fan, {Yao Shan} and Rowe, {Jacob M.} and Cin, {Paola Dal} and Sandberg, {Avery A.}",

note = "Funding Information: This work was supported in part by a grant CA-41285 from the National Cancer Institute. The authors thank Joan Schumer, Sharon Zolnowski, Linda Calvert, and Anne Marie Du-linawka for their technical and clerical assistance.",

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T1 - A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-L2)

AU - Fan, Yao Shan

AU - Rowe, Jacob M.

AU - Cin, Paola Dal

AU - Sandberg, Avery A.

N1 - Funding Information: This work was supported in part by a grant CA-41285 from the National Cancer Institute. The authors thank Joan Schumer, Sharon Zolnowski, Linda Calvert, and Anne Marie Du-linawka for their technical and clerical assistance.

PY - 1988/4

Y1 - 1988/4

N2 - We here report a t(9;11)(p11;q23) as the only abnormality in the affected cells of a 20-year-old male with acute lymphoblastic leukemia (L2) of T-cell origin. One hundred six patients with acute leukemia and involvement of band 11q23 were reviewed. Young age, hyperleukocytosis, and poor prognosis characterized almost all the cases in the acute leukemias with the 11q23 translocation, despite involvement of different recipient chromosomes and different morphologic and immunologic phenotypes.

AB - We here report a t(9;11)(p11;q23) as the only abnormality in the affected cells of a 20-year-old male with acute lymphoblastic leukemia (L2) of T-cell origin. One hundred six patients with acute leukemia and involvement of band 11q23 were reviewed. Young age, hyperleukocytosis, and poor prognosis characterized almost all the cases in the acute leukemias with the 11q23 translocation, despite involvement of different recipient chromosomes and different morphologic and immunologic phenotypes.

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A translocation t(9;11)(p11;q23) in T-cell acute lymphoblastic leukemia (FAB-L2)

Abstract

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