A Transcriptional Pause Synchronizes Translation with Transcription in the Tryptophanase Operon Leader Region

Feng Gong, Charles Yanofsky

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Regulation of transcription of the tryptophanase operon requires that translation of its leader peptide coding region, tnaC, be coupled with its transcription. We show in vitro that a transcription pause site exists at the end of the tnaC coding region and that translation of tnaC releases the paused transcription complex, coupling transcription with translation.

Original languageEnglish (US)
Pages (from-to)6472-6476
Number of pages5
JournalJournal of bacteriology
Volume185
Issue number21
DOIs
StatePublished - Nov 1 2003

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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