A Transcriptional Pause Synchronizes Translation with Transcription in the Tryptophanase Operon Leader Region

Feng Gong; Charles Yanofsky

doi:10.1128/JB.185.21.6472-6476.2003

A Transcriptional Pause Synchronizes Translation with Transcription in the Tryptophanase Operon Leader Region

Feng Gong, Charles Yanofsky

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Regulation of transcription of the tryptophanase operon requires that translation of its leader peptide coding region, tnaC, be coupled with its transcription. We show in vitro that a transcription pause site exists at the end of the tnaC coding region and that translation of tnaC releases the paused transcription complex, coupling transcription with translation.

Original language	English (US)
Pages (from-to)	6472-6476
Number of pages	5
Journal	Journal of bacteriology
Volume	185
Issue number	21
DOIs	https://doi.org/10.1128/JB.185.21.6472-6476.2003
State	Published - Nov 2003
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology

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abstract = "Regulation of transcription of the tryptophanase operon requires that translation of its leader peptide coding region, tnaC, be coupled with its transcription. We show in vitro that a transcription pause site exists at the end of the tnaC coding region and that translation of tnaC releases the paused transcription complex, coupling transcription with translation.",

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