A systematic review of prolotherapy for chronic musculoskeletal pain

David Rabago, Thomas Best, Mark Beamsley, Jeffrey Patterson

Research output: Contribution to journalReview article

94 Citations (Scopus)

Abstract

Objective: Prolotherapy, an injection-based treatment of chronic musculoskeletal pain, has grown in popularity and has received significant recent attention. The objective of this review is to determine the effectiveness of prolotherapy for treatment of chronic musculoskeletal pain. Data Sources: We searched Medline, PreMedline, Embase, CINAHL, and Allied and Complementary Medicine with search strategies using all current and historical names for prolotherapy and injectants. Reference sections of included articles were scanned, and content area specialists were consulted. Study Selection: All published studies involving human subjects and assessing prolotherapy were included. Main Results: Data from 34 case reports and case series and 2 nonrandomized controlled trials suggest prolotherapy is efficacious for many musculoskeletal conditions. However, results from 6 randomized controlled trials (RCTs) are conflicting. Two RCTs on osteoarthritis reported decreased pain, increased range of motion, and increased patellofemoral cartilage thickness after prolotherapy. Two RCTs on low back pain reported significant improvements in pain and disability compared with control subjects, whereas 2 did not. All studies had significant methodological limitations. Conclusions: There are limited high-quality data supporting the use of prolotherapy in the treatment of musculoskeletal pain or sport-related soft tissue injuries. Positive results compared with controls have been reported in nonrandomized and randomized controlled trials. Further investigation with high-quality randomized controlled trials with noninjection control arms in studies specific to sport-related and musculoskeletal conditions is necessary to determine the efficacy of prolotherapy.

Original languageEnglish (US)
Pages (from-to)376-380
Number of pages5
JournalClinical Journal of Sport Medicine
Volume15
Issue number5
StatePublished - Sep 1 2005
Externally publishedYes

Fingerprint

Musculoskeletal Pain
Chronic Pain
Randomized Controlled Trials
Sports
Pain
Soft Tissue Injuries
Information Storage and Retrieval
Complementary Therapies
Articular Range of Motion
Low Back Pain
Osteoarthritis
Cartilage
Names
Injections
Therapeutics

Keywords

  • Chronic pain
  • Low back pain
  • Osteoarthritis
  • Prolotherapy
  • Sclerotherapy

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

A systematic review of prolotherapy for chronic musculoskeletal pain. / Rabago, David; Best, Thomas; Beamsley, Mark; Patterson, Jeffrey.

In: Clinical Journal of Sport Medicine, Vol. 15, No. 5, 01.09.2005, p. 376-380.

Research output: Contribution to journalReview article

Rabago, D, Best, T, Beamsley, M & Patterson, J 2005, 'A systematic review of prolotherapy for chronic musculoskeletal pain', Clinical Journal of Sport Medicine, vol. 15, no. 5, pp. 376-380.
Rabago, David ; Best, Thomas ; Beamsley, Mark ; Patterson, Jeffrey. / A systematic review of prolotherapy for chronic musculoskeletal pain. In: Clinical Journal of Sport Medicine. 2005 ; Vol. 15, No. 5. pp. 376-380.
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