A System for Automatic Adjustment of the Inspired Oxygen in Mechanically Ventilated Premature Infants

Research output: Contribution to journalConference article

Abstract

Episodes of hypoxemia are often observed in ventilated preterm infants. Assistance with a transient increase in the fraction of inspired oxygen (FiO 2) is difficult and time consuming for the intensive care personnel. In order to reduce the morbidities associated with hypoxemia and oxygen toxicity, a system for closed loop control of FiO 2 (cFiO 2) was developed to respond to frequent and severe hypoxemic episodes and minimize oxygen exposure. The cFiO 2 system is based on a hybrid algorithm of rule based and differential feedback control. It automatically adjusts FiO 2 depending on the occurrence of the severity, duration, rate of change of the ensuing/resolving hypoxemia, and on the basal FiO 2 required to maintain oxygenation. In a clinical study, cFiO 2 was compared to a dedicated trained nurse managing the FiO 2 in a group of ventilated preterm infants and it was effective in limiting the duration and severity of hypoxemia. Close loop FiO 2 control could improve the respiratory, ophthalmic and neurological outcome and facilitate the care of premature neonates.

Original languageEnglish (US)
Pages (from-to)454-455
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - Dec 1 2003
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Keywords

  • Automatic
  • Closed loop
  • Oxygen

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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