A Survey of Cutaneous Neural Lesions for the Presence of Myelin Basic Protein: An Immunohistochemical Study

Neal S. Penneys, Rafaella Mogollon, Alexander Kowalczyk, Mehrdad Nadji, Kenji Adachi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The presence of myelin basic protein (MBP) within a skin neoplasm would support its derivation from Schwann's cells, since this substance is routinely present within Schwann's cells in the peripheral nervous system. Using a monoclonal antibody prepared against MBP and an unlabeled antibody peroxidase-antiperoxidase assay, we surveyed a variety of skin lesions suspected of being derived from Schwann's cells to determine whether MBP was present. Myelin basic protein was detected within the cytoplasm of cells composing benign solitary schwannoma (neurilemoma) and neurofibroma, confirming the association of these lesions with proliferation of Schwann's cells. Myelin basic protein was not found in a variety of intradermal and compound nevus cell nevi nor in malignant melanoma. This negative finding supports electron microscopic evidence suggesting that nevus cells have no relationship to Schwann's cells even though some nevus cell arrangements suggest Schwann's cell derivation under the light microscope.

Original languageEnglish (US)
Pages (from-to)210-213
Number of pages4
JournalArchives of Dermatology
Volume120
Issue number2
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Myelin Basic Protein
Schwann Cells
Skin
Nevus
Neurilemmoma
Intradermal Nevus
Neurofibroma
Peripheral Nervous System
Skin Neoplasms
Peroxidase
Surveys and Questionnaires
Melanoma
Cytoplasm
Monoclonal Antibodies
Electrons
Light
Antibodies

ASJC Scopus subject areas

  • Dermatology

Cite this

A Survey of Cutaneous Neural Lesions for the Presence of Myelin Basic Protein : An Immunohistochemical Study. / Penneys, Neal S.; Mogollon, Rafaella; Kowalczyk, Alexander; Nadji, Mehrdad; Adachi, Kenji.

In: Archives of Dermatology, Vol. 120, No. 2, 1984, p. 210-213.

Research output: Contribution to journalArticle

Penneys, Neal S. ; Mogollon, Rafaella ; Kowalczyk, Alexander ; Nadji, Mehrdad ; Adachi, Kenji. / A Survey of Cutaneous Neural Lesions for the Presence of Myelin Basic Protein : An Immunohistochemical Study. In: Archives of Dermatology. 1984 ; Vol. 120, No. 2. pp. 210-213.
@article{c971a48858e54916b3479d8de52efcd0,
title = "A Survey of Cutaneous Neural Lesions for the Presence of Myelin Basic Protein: An Immunohistochemical Study",
abstract = "The presence of myelin basic protein (MBP) within a skin neoplasm would support its derivation from Schwann's cells, since this substance is routinely present within Schwann's cells in the peripheral nervous system. Using a monoclonal antibody prepared against MBP and an unlabeled antibody peroxidase-antiperoxidase assay, we surveyed a variety of skin lesions suspected of being derived from Schwann's cells to determine whether MBP was present. Myelin basic protein was detected within the cytoplasm of cells composing benign solitary schwannoma (neurilemoma) and neurofibroma, confirming the association of these lesions with proliferation of Schwann's cells. Myelin basic protein was not found in a variety of intradermal and compound nevus cell nevi nor in malignant melanoma. This negative finding supports electron microscopic evidence suggesting that nevus cells have no relationship to Schwann's cells even though some nevus cell arrangements suggest Schwann's cell derivation under the light microscope.",
author = "Penneys, {Neal S.} and Rafaella Mogollon and Alexander Kowalczyk and Mehrdad Nadji and Kenji Adachi",
year = "1984",
doi = "10.1001/archderm.1984.01650380070013",
language = "English (US)",
volume = "120",
pages = "210--213",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - A Survey of Cutaneous Neural Lesions for the Presence of Myelin Basic Protein

T2 - An Immunohistochemical Study

AU - Penneys, Neal S.

AU - Mogollon, Rafaella

AU - Kowalczyk, Alexander

AU - Nadji, Mehrdad

AU - Adachi, Kenji

PY - 1984

Y1 - 1984

N2 - The presence of myelin basic protein (MBP) within a skin neoplasm would support its derivation from Schwann's cells, since this substance is routinely present within Schwann's cells in the peripheral nervous system. Using a monoclonal antibody prepared against MBP and an unlabeled antibody peroxidase-antiperoxidase assay, we surveyed a variety of skin lesions suspected of being derived from Schwann's cells to determine whether MBP was present. Myelin basic protein was detected within the cytoplasm of cells composing benign solitary schwannoma (neurilemoma) and neurofibroma, confirming the association of these lesions with proliferation of Schwann's cells. Myelin basic protein was not found in a variety of intradermal and compound nevus cell nevi nor in malignant melanoma. This negative finding supports electron microscopic evidence suggesting that nevus cells have no relationship to Schwann's cells even though some nevus cell arrangements suggest Schwann's cell derivation under the light microscope.

AB - The presence of myelin basic protein (MBP) within a skin neoplasm would support its derivation from Schwann's cells, since this substance is routinely present within Schwann's cells in the peripheral nervous system. Using a monoclonal antibody prepared against MBP and an unlabeled antibody peroxidase-antiperoxidase assay, we surveyed a variety of skin lesions suspected of being derived from Schwann's cells to determine whether MBP was present. Myelin basic protein was detected within the cytoplasm of cells composing benign solitary schwannoma (neurilemoma) and neurofibroma, confirming the association of these lesions with proliferation of Schwann's cells. Myelin basic protein was not found in a variety of intradermal and compound nevus cell nevi nor in malignant melanoma. This negative finding supports electron microscopic evidence suggesting that nevus cells have no relationship to Schwann's cells even though some nevus cell arrangements suggest Schwann's cell derivation under the light microscope.

UR - http://www.scopus.com/inward/record.url?scp=84943442874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943442874&partnerID=8YFLogxK

U2 - 10.1001/archderm.1984.01650380070013

DO - 10.1001/archderm.1984.01650380070013

M3 - Article

C2 - 6198973

AN - SCOPUS:84943442874

VL - 120

SP - 210

EP - 213

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 2

ER -