A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago

Talia Donenberg, Humayun Ahmed, Robert Royer, Shiyu Zhang, Steven A. Narod, Sophia George, Mohammad R. Akbari, Jameel Ali, Judith Hurley

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The mortality rate from breast cancer in the nation of Trinidad and Tobago is among the highest of any country in the Caribbean region. The contribution of inherited gene mutations to the burden of breast cancer in Trinidad and Tobago has not been studied. We examined the prevalence of mutations in three susceptibility genes (BRCA1, BRCA2, and PALB2) in breast cancer patients in Trinidad and Tobago. We studied 268 unselected breast cancer patients from Trinidad and Tobago and looked for mutations across the entire coding sequences of BRCA1, BRCA2, and PALB2. Overall, 28 of 268 patients (10.4 %) had a mutation in one of the three genes, including 15 in BRCA1, ten in BRCA2, two in PALB2, and one in both BRCA2 and PALB2. There were 25 different mutations identified; of these, four mutations were seen in two patients each. Given the high prevalence of mutations, it is reasonable to offer genetic testing for these three genes to all breast cancer patients in Trinidad and Tobago.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBreast Cancer Research and Treatment
DOIs
StateAccepted/In press - Jul 28 2016

Fingerprint

Trinidad and Tobago
Breast Neoplasms
Mutation
BRCA2 Gene
BRCA1 Gene
Genes
Genetic Testing
Surveys and Questionnaires
Mortality

Keywords

  • Bahamas
  • BRCA1
  • Breast cancer
  • Hereditary

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago. / Donenberg, Talia; Ahmed, Humayun; Royer, Robert; Zhang, Shiyu; Narod, Steven A.; George, Sophia; Akbari, Mohammad R.; Ali, Jameel; Hurley, Judith.

In: Breast Cancer Research and Treatment, 28.07.2016, p. 1-8.

Research output: Contribution to journalArticle

Donenberg, Talia ; Ahmed, Humayun ; Royer, Robert ; Zhang, Shiyu ; Narod, Steven A. ; George, Sophia ; Akbari, Mohammad R. ; Ali, Jameel ; Hurley, Judith. / A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago. In: Breast Cancer Research and Treatment. 2016 ; pp. 1-8.
@article{e7bc848f04804037ac49307a5d957add,
title = "A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago",
abstract = "The mortality rate from breast cancer in the nation of Trinidad and Tobago is among the highest of any country in the Caribbean region. The contribution of inherited gene mutations to the burden of breast cancer in Trinidad and Tobago has not been studied. We examined the prevalence of mutations in three susceptibility genes (BRCA1, BRCA2, and PALB2) in breast cancer patients in Trinidad and Tobago. We studied 268 unselected breast cancer patients from Trinidad and Tobago and looked for mutations across the entire coding sequences of BRCA1, BRCA2, and PALB2. Overall, 28 of 268 patients (10.4 {\%}) had a mutation in one of the three genes, including 15 in BRCA1, ten in BRCA2, two in PALB2, and one in both BRCA2 and PALB2. There were 25 different mutations identified; of these, four mutations were seen in two patients each. Given the high prevalence of mutations, it is reasonable to offer genetic testing for these three genes to all breast cancer patients in Trinidad and Tobago.",
keywords = "Bahamas, BRCA1, Breast cancer, Hereditary",
author = "Talia Donenberg and Humayun Ahmed and Robert Royer and Shiyu Zhang and Narod, {Steven A.} and Sophia George and Akbari, {Mohammad R.} and Jameel Ali and Judith Hurley",
year = "2016",
month = "7",
day = "28",
doi = "10.1007/s10549-016-3870-4",
language = "English (US)",
pages = "1--8",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",

}

TY - JOUR

T1 - A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago

AU - Donenberg, Talia

AU - Ahmed, Humayun

AU - Royer, Robert

AU - Zhang, Shiyu

AU - Narod, Steven A.

AU - George, Sophia

AU - Akbari, Mohammad R.

AU - Ali, Jameel

AU - Hurley, Judith

PY - 2016/7/28

Y1 - 2016/7/28

N2 - The mortality rate from breast cancer in the nation of Trinidad and Tobago is among the highest of any country in the Caribbean region. The contribution of inherited gene mutations to the burden of breast cancer in Trinidad and Tobago has not been studied. We examined the prevalence of mutations in three susceptibility genes (BRCA1, BRCA2, and PALB2) in breast cancer patients in Trinidad and Tobago. We studied 268 unselected breast cancer patients from Trinidad and Tobago and looked for mutations across the entire coding sequences of BRCA1, BRCA2, and PALB2. Overall, 28 of 268 patients (10.4 %) had a mutation in one of the three genes, including 15 in BRCA1, ten in BRCA2, two in PALB2, and one in both BRCA2 and PALB2. There were 25 different mutations identified; of these, four mutations were seen in two patients each. Given the high prevalence of mutations, it is reasonable to offer genetic testing for these three genes to all breast cancer patients in Trinidad and Tobago.

AB - The mortality rate from breast cancer in the nation of Trinidad and Tobago is among the highest of any country in the Caribbean region. The contribution of inherited gene mutations to the burden of breast cancer in Trinidad and Tobago has not been studied. We examined the prevalence of mutations in three susceptibility genes (BRCA1, BRCA2, and PALB2) in breast cancer patients in Trinidad and Tobago. We studied 268 unselected breast cancer patients from Trinidad and Tobago and looked for mutations across the entire coding sequences of BRCA1, BRCA2, and PALB2. Overall, 28 of 268 patients (10.4 %) had a mutation in one of the three genes, including 15 in BRCA1, ten in BRCA2, two in PALB2, and one in both BRCA2 and PALB2. There were 25 different mutations identified; of these, four mutations were seen in two patients each. Given the high prevalence of mutations, it is reasonable to offer genetic testing for these three genes to all breast cancer patients in Trinidad and Tobago.

KW - Bahamas

KW - BRCA1

KW - Breast cancer

KW - Hereditary

UR - http://www.scopus.com/inward/record.url?scp=84979988098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979988098&partnerID=8YFLogxK

U2 - 10.1007/s10549-016-3870-4

DO - 10.1007/s10549-016-3870-4

M3 - Article

C2 - 27469594

AN - SCOPUS:84979988098

SP - 1

EP - 8

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

ER -