A study of retrieved allografts used to replace anterior cruciate ligaments

Theodore Malinin, Richard L. Levitt, Christopher Bashore, H. Thomas Temple, Walid Mnaymneh

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Purpose: The purpose of the study was the examination of retrieved whole anterior cruciate ligament (ACL) replacement grafts to determine the rate and the extent of cellular replacement and remodeling of the grafts. Type of Study: Gross and histopathologic examination of specimens. Methods: Nine specimens of ACL replacement allografts and 1 autograft were obtained at autopsy and surgical procedures. Results: Examination of these specimens from 20 days to 10 years after transplantation revealed a pattern of revascularization similar to that reported in previous biopsy studies. However, examination of the entire allografts showed that, at 2 years after transplantation, the central portions of the grafts remained acellular and that complete attachment was not present, but was found in a 3.5-year post-transplantation specimen. Conclusions: Because attachment of the graft to bone tunnel walls required over 2 years, the tunnel remodeling may be explained on a mechanical basis. The remodeling of ACL replacement grafts is a gradual or slow process. Complete remodeling and cellular replacement of the entire graft may require 3 years or longer.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalArthroscopy
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2002

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Anterior Cruciate Ligament
Allografts
Transplants
Transplantation
Autografts
Autopsy
Biopsy
Bone and Bones

Keywords

  • ACL
  • Allograft
  • Histology
  • Remodeling
  • Replacement
  • Retrieval

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Malinin, T., Levitt, R. L., Bashore, C., Thomas Temple, H., & Mnaymneh, W. (2002). A study of retrieved allografts used to replace anterior cruciate ligaments. Arthroscopy, 18(2), 163-170. https://doi.org/10.1053/jars.2002.30485

A study of retrieved allografts used to replace anterior cruciate ligaments. / Malinin, Theodore; Levitt, Richard L.; Bashore, Christopher; Thomas Temple, H.; Mnaymneh, Walid.

In: Arthroscopy, Vol. 18, No. 2, 01.02.2002, p. 163-170.

Research output: Contribution to journalArticle

Malinin, T, Levitt, RL, Bashore, C, Thomas Temple, H & Mnaymneh, W 2002, 'A study of retrieved allografts used to replace anterior cruciate ligaments', Arthroscopy, vol. 18, no. 2, pp. 163-170. https://doi.org/10.1053/jars.2002.30485
Malinin T, Levitt RL, Bashore C, Thomas Temple H, Mnaymneh W. A study of retrieved allografts used to replace anterior cruciate ligaments. Arthroscopy. 2002 Feb 1;18(2):163-170. https://doi.org/10.1053/jars.2002.30485
Malinin, Theodore ; Levitt, Richard L. ; Bashore, Christopher ; Thomas Temple, H. ; Mnaymneh, Walid. / A study of retrieved allografts used to replace anterior cruciate ligaments. In: Arthroscopy. 2002 ; Vol. 18, No. 2. pp. 163-170.
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