A study of recurrence and death from papillary thyroid cancer with 27 years of median follow-up

Raymon H. Grogan, Sharone P. Kaplan, Hongyuan Cao, Roy E Weiss, Leslie J. Degroot, Cassie A. Simon, Omran M A Embia, Peter Angelos, Edwin L. Kaplan, Rebecca B. Schechter

Research output: Contribution to journalArticle

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Abstract

Background Although recurrence and death can occur in patients with papillary thyroid cancer (PTC) several years after being diagnosed, the necessary duration of follow-up for these patients remains unclear. Methods This was a single-institution, retrospective review of 269 patients with PTC. Cox proportional hazards model and Kaplan-Meier curves were used to identify risk factors for recurrence and death. Risk predictors included age, sex, radiation exposure history, extent of operation, radioactive iodine treatment, follicular variant of PTC (FVPTC), extrathyroidal invasion, multifocality, TNM status, and stage. Results Median follow-up was 27 years. Of 269 patients, 180 (66%) were female, and 196 (73%) were ≤45 years of age. Recurrence and cancer-specific death rates were 28% and 9%, respectively. Time to recurrence (±SD) was 8.1 (± 8.3) years and to cancer-specific death was 9.0 (± 11.0) years; however, 11% of recurrences and 17% of deaths occurred after 20 years. Risk factors for recurrence were older age, FVPTC, T4 tumors, cervical lymph node involvement, metastases, and stage ≥ 4a. Predictors of death from PTC were older age, metastases, and stage ≥ 3. Conclusion Both recurrences and death from PTC can occur more than 30 years after being treated, thus lifelong follow-up of patients with PTC is necessary.

Original languageEnglish (US)
Pages (from-to)1436-1447
Number of pages12
JournalSurgery (United States)
Volume154
Issue number6
DOIs
StatePublished - Dec 2013
Externally publishedYes

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Recurrence
Neoplasm Metastasis
Neoplasms
Factor IX
Papillary Thyroid cancer
Proportional Hazards Models
Iodine
Lymph Nodes
Mortality
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Grogan, R. H., Kaplan, S. P., Cao, H., Weiss, R. E., Degroot, L. J., Simon, C. A., ... Schechter, R. B. (2013). A study of recurrence and death from papillary thyroid cancer with 27 years of median follow-up. Surgery (United States), 154(6), 1436-1447. https://doi.org/10.1016/j.surg.2013.07.008

A study of recurrence and death from papillary thyroid cancer with 27 years of median follow-up. / Grogan, Raymon H.; Kaplan, Sharone P.; Cao, Hongyuan; Weiss, Roy E; Degroot, Leslie J.; Simon, Cassie A.; Embia, Omran M A; Angelos, Peter; Kaplan, Edwin L.; Schechter, Rebecca B.

In: Surgery (United States), Vol. 154, No. 6, 12.2013, p. 1436-1447.

Research output: Contribution to journalArticle

Grogan, RH, Kaplan, SP, Cao, H, Weiss, RE, Degroot, LJ, Simon, CA, Embia, OMA, Angelos, P, Kaplan, EL & Schechter, RB 2013, 'A study of recurrence and death from papillary thyroid cancer with 27 years of median follow-up', Surgery (United States), vol. 154, no. 6, pp. 1436-1447. https://doi.org/10.1016/j.surg.2013.07.008
Grogan, Raymon H. ; Kaplan, Sharone P. ; Cao, Hongyuan ; Weiss, Roy E ; Degroot, Leslie J. ; Simon, Cassie A. ; Embia, Omran M A ; Angelos, Peter ; Kaplan, Edwin L. ; Schechter, Rebecca B. / A study of recurrence and death from papillary thyroid cancer with 27 years of median follow-up. In: Surgery (United States). 2013 ; Vol. 154, No. 6. pp. 1436-1447.
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abstract = "Background Although recurrence and death can occur in patients with papillary thyroid cancer (PTC) several years after being diagnosed, the necessary duration of follow-up for these patients remains unclear. Methods This was a single-institution, retrospective review of 269 patients with PTC. Cox proportional hazards model and Kaplan-Meier curves were used to identify risk factors for recurrence and death. Risk predictors included age, sex, radiation exposure history, extent of operation, radioactive iodine treatment, follicular variant of PTC (FVPTC), extrathyroidal invasion, multifocality, TNM status, and stage. Results Median follow-up was 27 years. Of 269 patients, 180 (66{\%}) were female, and 196 (73{\%}) were ≤45 years of age. Recurrence and cancer-specific death rates were 28{\%} and 9{\%}, respectively. Time to recurrence (±SD) was 8.1 (± 8.3) years and to cancer-specific death was 9.0 (± 11.0) years; however, 11{\%} of recurrences and 17{\%} of deaths occurred after 20 years. Risk factors for recurrence were older age, FVPTC, T4 tumors, cervical lymph node involvement, metastases, and stage ≥ 4a. Predictors of death from PTC were older age, metastases, and stage ≥ 3. Conclusion Both recurrences and death from PTC can occur more than 30 years after being treated, thus lifelong follow-up of patients with PTC is necessary.",
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AU - Kaplan, Sharone P.

AU - Cao, Hongyuan

AU - Weiss, Roy E

AU - Degroot, Leslie J.

AU - Simon, Cassie A.

AU - Embia, Omran M A

AU - Angelos, Peter

AU - Kaplan, Edwin L.

AU - Schechter, Rebecca B.

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N2 - Background Although recurrence and death can occur in patients with papillary thyroid cancer (PTC) several years after being diagnosed, the necessary duration of follow-up for these patients remains unclear. Methods This was a single-institution, retrospective review of 269 patients with PTC. Cox proportional hazards model and Kaplan-Meier curves were used to identify risk factors for recurrence and death. Risk predictors included age, sex, radiation exposure history, extent of operation, radioactive iodine treatment, follicular variant of PTC (FVPTC), extrathyroidal invasion, multifocality, TNM status, and stage. Results Median follow-up was 27 years. Of 269 patients, 180 (66%) were female, and 196 (73%) were ≤45 years of age. Recurrence and cancer-specific death rates were 28% and 9%, respectively. Time to recurrence (±SD) was 8.1 (± 8.3) years and to cancer-specific death was 9.0 (± 11.0) years; however, 11% of recurrences and 17% of deaths occurred after 20 years. Risk factors for recurrence were older age, FVPTC, T4 tumors, cervical lymph node involvement, metastases, and stage ≥ 4a. Predictors of death from PTC were older age, metastases, and stage ≥ 3. Conclusion Both recurrences and death from PTC can occur more than 30 years after being treated, thus lifelong follow-up of patients with PTC is necessary.

AB - Background Although recurrence and death can occur in patients with papillary thyroid cancer (PTC) several years after being diagnosed, the necessary duration of follow-up for these patients remains unclear. Methods This was a single-institution, retrospective review of 269 patients with PTC. Cox proportional hazards model and Kaplan-Meier curves were used to identify risk factors for recurrence and death. Risk predictors included age, sex, radiation exposure history, extent of operation, radioactive iodine treatment, follicular variant of PTC (FVPTC), extrathyroidal invasion, multifocality, TNM status, and stage. Results Median follow-up was 27 years. Of 269 patients, 180 (66%) were female, and 196 (73%) were ≤45 years of age. Recurrence and cancer-specific death rates were 28% and 9%, respectively. Time to recurrence (±SD) was 8.1 (± 8.3) years and to cancer-specific death was 9.0 (± 11.0) years; however, 11% of recurrences and 17% of deaths occurred after 20 years. Risk factors for recurrence were older age, FVPTC, T4 tumors, cervical lymph node involvement, metastases, and stage ≥ 4a. Predictors of death from PTC were older age, metastases, and stage ≥ 3. Conclusion Both recurrences and death from PTC can occur more than 30 years after being treated, thus lifelong follow-up of patients with PTC is necessary.

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