A spontaneous outbreak of polycholorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): Toxicopathology

E. E. McConnell, J. R. Hass, N. Altman, J. A. Moore

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Scopus citations

Abstract

Polychlorinated biphenyls were shown to be the cause of a wasting syndrome and reproductive dysfunction in a group of rhesus monkeys (Macaca mulatta). The polychlorinated biphenyls were found by gas chromatographic analysis in high amounts in the superficial layers of the concrete slab floors in the housing facility. The concrete sealant was suspected as the original source although it is not known whether it contained polychlorinated biphenyls before it was applied or if it was contaminated later. Histopathologic findings for the most part were confined to epithelial tissues where squamous metaplasia of several glandular tissues was observed. A striking finding was severe hypertrophy of the glandular stomach and a similar but less severe lesion in the colon. The lesions may be related in part to impaired vitamin A metabolism, but not to a dietary deficiency.

Original languageEnglish
Title of host publicationLaboratory Animal Science
Pages666-673
Number of pages8
Volume29
Edition5
StatePublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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