A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): Clinical observations

N. H. Altman, A. E. New, E. E. McConnell, T. L. Ferrell

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

A spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (Macaca mulatta). The disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. Breeding efficiency was impaired with a high incidence of abortions and stillbirths. Live offspring were small and unthrifty contributing to a high infant mortality rate. The cause of this disease was polychlorinated biphenyls (PCBs) which were present in the concrete sealant on the cage floors. Removing the sealant and resurfacing the floors alleviated the problem.

Original languageEnglish
Title of host publicationLaboratory Animal Science
Pages661-665
Number of pages5
Volume29
Edition5
StatePublished - Dec 1 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Altman, N. H., New, A. E., McConnell, E. E., & Ferrell, T. L. (1979). A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): Clinical observations. In Laboratory Animal Science (5 ed., Vol. 29, pp. 661-665)