A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): Clinical observations

N. H. Altman; A. E. New; E. E. McConnell; T. L. Ferrell

A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): Clinical observations

N. H. Altman, A. E. New, E. E. McConnell, T. L. Ferrell

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (Macaca mulatta). The disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. Breeding efficiency was impaired with a high incidence of abortions and stillbirths. Live offspring were small and unthrifty contributing to a high infant mortality rate. The cause of this disease was polychlorinated biphenyls (PCBs) which were present in the concrete sealant on the cage floors. Removing the sealant and resurfacing the floors alleviated the problem.

Original language	English
Title of host publication	Laboratory Animal Science
Pages	661-665
Number of pages	5
Volume	29
Edition	5
State	Published - Dec 1 1979
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): Clinical observations",

abstract = "A spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (Macaca mulatta). The disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. Breeding efficiency was impaired with a high incidence of abortions and stillbirths. Live offspring were small and unthrifty contributing to a high infant mortality rate. The cause of this disease was polychlorinated biphenyls (PCBs) which were present in the concrete sealant on the cage floors. Removing the sealant and resurfacing the floors alleviated the problem.",

author = "Altman, {N. H.} and New, {A. E.} and McConnell, {E. E.} and Ferrell, {T. L.}",

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T1 - A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta)

T2 - Clinical observations

AU - Altman, N. H.

AU - New, A. E.

AU - McConnell, E. E.

AU - Ferrell, T. L.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - A spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (Macaca mulatta). The disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. Breeding efficiency was impaired with a high incidence of abortions and stillbirths. Live offspring were small and unthrifty contributing to a high infant mortality rate. The cause of this disease was polychlorinated biphenyls (PCBs) which were present in the concrete sealant on the cage floors. Removing the sealant and resurfacing the floors alleviated the problem.

AB - A spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (Macaca mulatta). The disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. Breeding efficiency was impaired with a high incidence of abortions and stillbirths. Live offspring were small and unthrifty contributing to a high infant mortality rate. The cause of this disease was polychlorinated biphenyls (PCBs) which were present in the concrete sealant on the cage floors. Removing the sealant and resurfacing the floors alleviated the problem.

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