A spectraldiscrimination method for tearfilm lipidlayer thickness estimation from fringe pattern images

Ali Khamene, Shahriar Negahdaripour, Scheffer C.G. Tseng

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Examination of the tearfilm lipid layer is often helpful in the prognosis of prospective contact lens patients and contact lens related problems, and in the analysis of symptomatic noncontact lenswearing patients. In particular, the thickness of the lipid layer is considered to be an informative cue in studying the tearfilm stability and uncovering of certain disorders. We propose a method for the accurate estimation of the lipidlayer thickness, exploiting the intensity and color information in Fizeau fringe images. The technique is based on a quantitative measure for discriminating among the spectra associated with different thicknesses. We propose an optical system for imaging the interference patterns, develop a mathematical model based on the physics of the fringe formation and sensing, and describe the calibration of the optical system using this model. The thickness extraction is readily carried out utilizing a lookup table. The proposed method would enable objective evaluation of the lipid layer characteristics, and provide a means for examining the dynamic changes in its thickness and spatial distribution during interblink periods.

Original languageEnglish (US)
Number of pages1
JournalIEEE Transactions on Biomedical Engineering
Volume47
Issue number2
StatePublished - Dec 1 2000

Keywords

  • Fizeau fringe patterns
  • Interferometry and quantitative thickness estimation
  • Tearfilm lipid layer

ASJC Scopus subject areas

  • Biomedical Engineering

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