A simplified in vivo autoradiographic strategy for the determination of regional cerebral blood flow by positron emission tomography: Theoretical considerations and validation studies in the rat

M. D. Ginsberg, A. H. Lockwood, R. Busto, R. D. Finn, C. M. Butler, I. E. Cendan, J. Goddard

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

A simplified mathematical model is described for the measurement of regional cerebral blood-flow by positron-emission tomography in man, based on a modification of the autoradiographic strategy originally developed for experimental animal studies. A modified ramp intravenous infusion of radio-labeled tracer is used; this results in a monotonically-increasing curvilinear arterial activity-curve that may be accurately described by a polynomial of low degree. Integrated cranial activity is measured in regions of interest during the latter portion of the tracer-infusion period. An on-line computer solution for blood flow is presented. This in-vivo autoradiographic paradigm was validated in a series of rats by comparing it to the classical autoradiographic strategy developed by Kety and associates. Excellent agreement was demonstrated between blood-flow values obtained by the two methods.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
JournalUnknown Journal
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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