A signal transducer for aerotaxis in Escherichia coli

Sergei I. Bibikov, Roy Biran, Kenneth E. Rudd, John S. Parkinson

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

The newly discovered aer locus of Escherichia coli encodes a 506- residue protein with an N terminus that resembles the NifL aerosensor and a C terminus that resembles the flagellar signaling domain of methyl-accepting chemoreceptors. Deletion mutants lacking a functional Aer protein failed to congregate around air bubbles or follow oxygen gradients in soft agar plates. Membranes with overexpressed Aer protein also contained high levels of noncovalently associated flavin adenine dinucleotide (FAD). We propose that Aer is a flavoprotein that mediates positive aerotactic responses in E. coli. Aer may use its FAD prosthetic group as a cellular redox sensor to monitor environmental oxygen levels.

Original languageEnglish
Pages (from-to)4075-4079
Number of pages5
JournalJournal of Bacteriology
Volume179
Issue number12
StatePublished - Jun 1 1997
Externally publishedYes

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Transducers
Flavin-Adenine Dinucleotide
Escherichia coli
Oxygen
Flavoproteins
Proteins
Agar
Oxidation-Reduction
Air
Membranes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Bibikov, S. I., Biran, R., Rudd, K. E., & Parkinson, J. S. (1997). A signal transducer for aerotaxis in Escherichia coli. Journal of Bacteriology, 179(12), 4075-4079.

A signal transducer for aerotaxis in Escherichia coli. / Bibikov, Sergei I.; Biran, Roy; Rudd, Kenneth E.; Parkinson, John S.

In: Journal of Bacteriology, Vol. 179, No. 12, 01.06.1997, p. 4075-4079.

Research output: Contribution to journalArticle

Bibikov, SI, Biran, R, Rudd, KE & Parkinson, JS 1997, 'A signal transducer for aerotaxis in Escherichia coli', Journal of Bacteriology, vol. 179, no. 12, pp. 4075-4079.
Bibikov SI, Biran R, Rudd KE, Parkinson JS. A signal transducer for aerotaxis in Escherichia coli. Journal of Bacteriology. 1997 Jun 1;179(12):4075-4079.
Bibikov, Sergei I. ; Biran, Roy ; Rudd, Kenneth E. ; Parkinson, John S. / A signal transducer for aerotaxis in Escherichia coli. In: Journal of Bacteriology. 1997 ; Vol. 179, No. 12. pp. 4075-4079.
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