A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort

Elisabeth B. Binder, D. Jeffrey Newport, Elizabeth B. Zach, Alicia K. Smith, Todd C. Deveau, Lori L. Altshuler, Lee S. Cohen, Zachary N. Stowe, Joseph F. Cubells

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Backgroud: Peripartum major depressive disorder (MDD) is a prevalent psychiatric disorder with potential detrimental consequences for both mother and child. Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population. Methods: Two hundred and seventy four women with a prior history of MDD were genotyped for 5-HTTLPR and serially evaluated in late pregnancy (gestational weeks 31-40), early post-partum (week 1-8) and late post-partum (week 9-24) for diagnosis of a current major depressive episode (MDE) and depressive symptom severity. Results: 5-HTTLPR S-allele carrier status predicted the occurrence of a MDE in the early post-partum period only (OR. =5.13, p=0.017). This association persisted despite continued antidepressant treatment. Conclusions: The 5-HTTLPR genotype may be a clinically relevant predictor of early post-partum depression in an at-risk population. Objective: Peripartum major depressive disorder is a prevalent psychiatric disorder with potential detrimental consequences for both mother and child. Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population.

Original languageEnglish (US)
Pages (from-to)640-646
Number of pages7
JournalJournal of Psychiatric Research
Volume44
Issue number10
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

Keywords

  • 5-HTTLPR
  • At-risk population
  • Peripartum depression
  • Polymorphism
  • Pregnancy
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Binder, E. B., Jeffrey Newport, D., Zach, E. B., Smith, A. K., Deveau, T. C., Altshuler, L. L., Cohen, L. S., Stowe, Z. N., & Cubells, J. F. (2010). A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort. Journal of Psychiatric Research, 44(10), 640-646. https://doi.org/10.1016/j.jpsychires.2009.12.001