A selective optical sensor based on [9]mercuracarborand-3, a new type of lonophore with a chloride complexing cavity

Ibrahim H.A. Badr, R. Daniel Johnson, Martin Diaz, M. Frederick Hawthorne, Leonidas G. Bachas

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


A highly selective optical sensor for chloride, based on the multidentate Lewis acid ionophore [9]mercuracarborand-3, is described herein. This sensor is constructed by embedding the mercuracarborand ionophore, a suitable pH-sensitive lipophilic dye, and lipophilic cationic sites in a plasticized polymeric membrane. The multiple complementary interactions offered by the preorganized complexing cavity of [9]mercuracarborand-3 is shown to control the anion selectivity pattern of the optical film. The film exhibits a significantly enhanced selectivity for chloride over a variety of lipophilic anions such as perchlorate, nitrate, salicylate, and thiocyanate. Furthermore, the optical selectivity coefficients obtained for chloride over other biologically relevant anions are shown to meet the selectivity requirements for the determination of chloride in physiological fluids, unlike previously reported chloride optical sensors. In addition, the optical film responds to chloride reversibly over a wide dynamic range (16 μM-136 mM) with fast response and recovery times.

Original languageEnglish (US)
Pages (from-to)4249-4254
Number of pages6
JournalAnalytical Chemistry
Issue number18
StatePublished - Sep 15 2000
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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