A Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia

Joseph D. Rosenblatt, David W. Golde, William Wachsman, Janis V. Giorgi, Andrew Jacobs, Gerhard M. Schmidt, Shirley Quan, Judith C. Gasson, Irvin S.y. Chen

Research output: Contribution to journalArticlepeer-review

186 Scopus citations

Abstract

THE human T-cell lymphotropic viruses Type I (HTLV-I) and Type II (HTLV-II) and the bovine leukemia virus, which are members of a family of leukemogenic mammalian retroviruses, share some of the same structural and functional characteristics. HTLV-I has been implicated as the causative agent of adult T-cell leukemia, a T-cell lymphoid malignant disease endemic to southern Japan and the Caribbean area.1 2 3 4 5 6 7 8 Bovine leukemia virus has been recognized as a cause of specific lymphoid malignant diseases of cattle.9 10 11 The role of HTLV-II in human cancer is unclear. This agent is a human retrovirus with a nucleic acid sequence homology to HTLV-I…

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalNew England Journal of Medicine
Volume315
Issue number6
DOIs
StatePublished - Aug 7 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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