A Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia

Joseph D. Rosenblatt; David W. Golde; William Wachsman; Janis V. Giorgi; Andrew Jacobs; Gerhard M. Schmidt; Shirley Quan; Judith C. Gasson; Irvin S.y. Chen

doi:10.1056/NEJM198608073150606

A Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia

Joseph D. Rosenblatt, David W. Golde, William Wachsman, Janis V. Giorgi, Andrew Jacobs, Gerhard M. Schmidt, Shirley Quan, Judith C. Gasson, Irvin S.y. Chen

Research output: Contribution to journal › Article › peer-review

192 Scopus citations

Abstract

THE human T-cell lymphotropic viruses Type I (HTLV-I) and Type II (HTLV-II) and the bovine leukemia virus, which are members of a family of leukemogenic mammalian retroviruses, share some of the same structural and functional characteristics. HTLV-I has been implicated as the causative agent of adult T-cell leukemia, a T-cell lymphoid malignant disease endemic to southern Japan and the Caribbean area.¹ ² ³ ⁴ ⁵ ⁶ ⁷ ⁸ Bovine leukemia virus has been recognized as a cause of specific lymphoid malignant diseases of cattle.⁹ ¹⁰ ¹¹ The role of HTLV-II in human cancer is unclear. This agent is a human retrovirus with a nucleic acid sequence homology to HTLV-I…

Original language	English (US)
Pages (from-to)	372-377
Number of pages	6
Journal	New England Journal of Medicine
Volume	315
Issue number	6
DOIs	https://doi.org/10.1056/NEJM198608073150606
State	Published - Aug 7 1986
Externally published	Yes

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A Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia. / Rosenblatt, Joseph D.; Golde, David W.; Wachsman, William; Giorgi, Janis V.; Jacobs, Andrew; Schmidt, Gerhard M.; Quan, Shirley; Gasson, Judith C.; Chen, Irvin S.y.

In: New England Journal of Medicine, Vol. 315, No. 6, 07.08.1986, p. 372-377.

Research output: Contribution to journal › Article › peer-review

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abstract = "THE human T-cell lymphotropic viruses Type I (HTLV-I) and Type II (HTLV-II) and the bovine leukemia virus, which are members of a family of leukemogenic mammalian retroviruses, share some of the same structural and functional characteristics. HTLV-I has been implicated as the causative agent of adult T-cell leukemia, a T-cell lymphoid malignant disease endemic to southern Japan and the Caribbean area.1 2 3 4 5 6 7 8 Bovine leukemia virus has been recognized as a cause of specific lymphoid malignant diseases of cattle.9 10 11 The role of HTLV-II in human cancer is unclear. This agent is a human retrovirus with a nucleic acid sequence homology to HTLV-I…",

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AU - Jacobs, Andrew

AU - Schmidt, Gerhard M.

AU - Quan, Shirley

AU - Gasson, Judith C.

AU - Chen, Irvin S.y.

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A Second Isolate of HTLV-II Associated with Atypical Hairy-Cell Leukemia

Abstract

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