A run on the biobank: What have we learned about type 1 diabetes from the nPOD tissue repository?

John S. Kaddis, Alberto Pugliese, Mark A. Atkinson

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Purpose of review Since the inaugural year of its biobank in 2007, the Network for Pancreatic Organ Donors with Diabetes program has provided 70370 human samples to 127 investigators worldwide for projects focused on the pathogenesis of type 1 diabetes (T1D). The purpose of this review was to highlight major advances in our understanding of T1D using works that contain original data from experiments utilizing biospecimens provided by the Network for Pancreatic Organ Donors with Diabetes program. A total of 15 studies, published between 1 June 2013 and 31 December 2014, were selected using various search and filter strategies. Recent findings The type and frequency of B and/or T-cell immune markers in both the endocrine and exocrine compartments vary in T1D. Enterovirus signals have been identified as having new proteins in the extracellular matrix around infiltrated islets. Novel genes within human islet cell types have been shown to play a role in immunity, infiltration, inflammation, disease progression, cell mass and function. Various cytokines and a complement degradation product have also been detected in the blood or surrounding pancreatic ducts/vasculature. Summary These findings, from T1D donors across the disease spectrum, emphasize the notion that pathogenic heterogeneity is a hallmark of the disorder.

Original languageEnglish (US)
Pages (from-to)290-295
Number of pages6
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume22
Issue number4
DOIs
StatePublished - Aug 23 2015

Keywords

  • atrophy
  • immunity
  • infiltration
  • pancreas
  • regeneration

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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