A role for carbohydrates in immune evasion in AIDS

Julie N. Reitter, Robert E. Means, Ronald C. Desrosiers

Research output: Contribution to journalArticle

495 Scopus citations

Abstract

Rhesus monkeys were infected with mutant forms of simian immunodeficiency virus lacking dual combinations of the 4th, 5th and 6th sites for N-linked glycosylation in the external envelope glycoprotein of the virus. When compared with sera from monkeys infected with the parental virus, sera from monkeys infected with the mutant viruses exhibited markedly increased antibody binding to specific peptides from this region and markedly increased neutralizing activity. These results demonstrate a role for N- linked glycosylation in limiting the neutralizing antibody response to SIV and in shielding the virus from immune recognition.

Original languageEnglish (US)
Pages (from-to)679-684
Number of pages6
JournalNature medicine
Volume4
Issue number6
DOIs
StatePublished - Jun 1 1998

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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