A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease

Tracy J. Doyle, Joyce S. Lee, Paul F. Dellaripa, James A. Lederer, Eric L. Matteson, Aryeh Fischer, Dana P. Ascherman, Marilyn K. Glassberg, Jay H. Ryu, Sonye K. Danoff, Kevin K. Brown, Harold R. Collard, Ivan O. Rosas

Research output: Contribution to journalComment/debate

36 Scopus citations

Abstract

Rheumatoid arthritis(RA) is a systemic infl ammatory disorder affecting approximately 1.3 million adults in the United States. Approximately 10% of these individuals with RA have clinically evident interstitial lung disease(RA-ILD), and an additional one-third demonstrate subclinical ILD on chest CT scan. The risk of death for individuals with RA-ILD is three times higher than for patients with RA without ILD, with a median survival after ILD diagnosis of only 2.6 years. Despite the high prevalence and mortality of RA-ILD, little is known about its molecular features and its natural history. At present, we lack a standard validated approach to the defi nition, diagnosis, risk stratification, and management of RA-ILD. In this perspective, we discuss the importance of clinical and translational research and how ongoing research efforts can address important gaps in our knowledge over the next few years. Furthermore, recommendations are made to design multicenter collaborative studies that will expedite the development of clinical trials designed to decrease the significant morbidity and mortality associated with RA-ILD.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalCHEST
Volume145
Issue number3
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Doyle, T. J., Lee, J. S., Dellaripa, P. F., Lederer, J. A., Matteson, E. L., Fischer, A., Ascherman, D. P., Glassberg, M. K., Ryu, J. H., Danoff, S. K., Brown, K. K., Collard, H. R., & Rosas, I. O. (2014). A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. CHEST, 145(3), 454-463. https://doi.org/10.1378/chest.13-2408