A Review of Photodynamic Therapy for Neoplasms of the Head and Neck

Francisco Civantos, Barış Karakullukcu, Merrill Biel, Carl E. Silver, Alessandra Rinaldo, Nabil F. Saba, Robert P. Takes, Vincent Vander Poorten, Alfio Ferlito

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) involves the use of a phototoxic drug which is activated by low powered laser light to destroy neoplastic cells. Multiple photosensitizers have been studied and tumors have been treated in a variety of head and neck sites over the last 30 years. PDT can effectively treat head and neck tumors, particularly those of the superficial spreading type, and the classic application of this technology has been in the patient with a wide field of dysplastic change and superficial carcinomatosis. Interstitial treatment has been used to treat more invasive cancer. Data is available from case series and institutional experiences, but very little randomized data is available. We review the mechanisms of action, historical development, available data, and current knowledge regarding PDT for the various head and neck subsites, and discuss possible future directions, with an emphasis on clinical application.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalAdvances in Therapy
DOIs
StateAccepted/In press - Feb 7 2018

Fingerprint

Photochemotherapy
Head and Neck Neoplasms
Neck
Head
Neoplasms
Photosensitizing Agents
Lasers
Technology
Carcinoma
Light
Pharmaceutical Preparations
Therapeutics

Keywords

  • Head and neck cancer
  • Laryngeal cancer
  • Lip cancer
  • Nasopharyngeal cancer
  • Oncology
  • Oral cavity cancer
  • Oropharyngeal cancer
  • Photodynamic therapy
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Civantos, F., Karakullukcu, B., Biel, M., Silver, C. E., Rinaldo, A., Saba, N. F., ... Ferlito, A. (Accepted/In press). A Review of Photodynamic Therapy for Neoplasms of the Head and Neck. Advances in Therapy, 1-17. https://doi.org/10.1007/s12325-018-0659-3

A Review of Photodynamic Therapy for Neoplasms of the Head and Neck. / Civantos, Francisco; Karakullukcu, Barış; Biel, Merrill; Silver, Carl E.; Rinaldo, Alessandra; Saba, Nabil F.; Takes, Robert P.; Vander Poorten, Vincent; Ferlito, Alfio.

In: Advances in Therapy, 07.02.2018, p. 1-17.

Research output: Contribution to journalArticle

Civantos, F, Karakullukcu, B, Biel, M, Silver, CE, Rinaldo, A, Saba, NF, Takes, RP, Vander Poorten, V & Ferlito, A 2018, 'A Review of Photodynamic Therapy for Neoplasms of the Head and Neck', Advances in Therapy, pp. 1-17. https://doi.org/10.1007/s12325-018-0659-3
Civantos, Francisco ; Karakullukcu, Barış ; Biel, Merrill ; Silver, Carl E. ; Rinaldo, Alessandra ; Saba, Nabil F. ; Takes, Robert P. ; Vander Poorten, Vincent ; Ferlito, Alfio. / A Review of Photodynamic Therapy for Neoplasms of the Head and Neck. In: Advances in Therapy. 2018 ; pp. 1-17.
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