A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies

Olivier Hermine; Juan Carlos Ramos; Kensei Tobinai

doi:10.1007/s12325-018-0658-4

A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies

Olivier Hermine, Juan Carlos Ramos, Kensei Tobinai

Medicine

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Adult T-cell leukemia–lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landscape as a number of existing and investigational agents are evaluated. We describe the epidemiology of HTLV-1 and ATL, discuss the biology behind the disease, review current treatment practices and guidelines, and provide an overview of emerging therapies in ATL, with a focus on those for relapsed or refractory disease.

Original language	English (US)
Pages (from-to)	135-152
Number of pages	18
Journal	Advances in Therapy
Volume	35
Issue number	2
DOIs	https://doi.org/10.1007/s12325-018-0658-4
State	Published - Feb 1 2018

Keywords

Adult T-cell leukemia–lymphoma
Chemotherapy
Human T-cell lymphotropic virus type 1
Oncology
Relapsed/refractory disease
Targeted agents

ASJC Scopus subject areas

Pharmacology (medical)

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abstract = "Adult T-cell leukemia–lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landscape as a number of existing and investigational agents are evaluated. We describe the epidemiology of HTLV-1 and ATL, discuss the biology behind the disease, review current treatment practices and guidelines, and provide an overview of emerging therapies in ATL, with a focus on those for relapsed or refractory disease.",

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