A review of clinical aspects of breast cancer

Shai Libson, Marc E Lippman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Breast cancer is the most frequently diagnosed cancer in women and ranks second among causes for cancer related death in women. The ability to identify and diagnose breast cancer has improved markedly. Treatment decisions which were based in the past predominantly on the anatomic extent of the disease are shifting to the underlying biological mechanisms. Gene array technology has led to the recognition that breast cancer is a heterogeneous disease composed of different biological subtypes, and genetic profiling enables response to chemotherapy to be predicted. Breast conservation became an established standard of care and the oncoplastic approach enables wide excisions without compromising the natural shape of the breast. Sentinel lymph node biopsy has replaced axillary dissection as the standard procedure to stage the axilla and spared many patients the excess morbidity of axillary dissection. Targeted therapy to the oestrogen receptor plays a major role in systemic therapy; pathways responsible for endocrine resistance have been targeted as well. Biological therapy has been developed to target HER2 receptor and combination of antibody drug conjugates linked cytotoxic therapy to HER2 antibodies. Meaningful improvements in survival resulted from the new effective systemic agents and patients with metastasis are likely to have a longer survival.

Original languageEnglish
Pages (from-to)4-15
Number of pages12
JournalInternational Review of Psychiatry
Volume26
Issue number1
DOIs
StatePublished - Feb 1 2014

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Breast Neoplasms
Dissection
Breast
Sentinel Lymph Node Biopsy
Biological Therapy
Axilla
Survival
Antibodies
Proxy
Drug Combinations
Therapeutics
Standard of Care
Estrogen Receptors
Neoplasms
Neoplasm Metastasis
Technology
Morbidity
Drug Therapy
Genes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A review of clinical aspects of breast cancer. / Libson, Shai; Lippman, Marc E.

In: International Review of Psychiatry, Vol. 26, No. 1, 01.02.2014, p. 4-15.

Research output: Contribution to journalArticle

Libson, Shai ; Lippman, Marc E. / A review of clinical aspects of breast cancer. In: International Review of Psychiatry. 2014 ; Vol. 26, No. 1. pp. 4-15.
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