A review of brain biorepository management and operations

H. Ronald Zielke, Deborah C. Mash

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Brain biospecimen banking requires centralized resources, national networks for referral of donors, trained personnel to interact with grieving families, and scientific staff to process the biospecimens. Process development of quality control standards is needed to meet the specific requirements of emerging genomic and proteomic technologies. Attention has to be paid to agonal factors and postmortem interval, tissue processing, neuropathology review, and long-term storage. Samples of both diseased and unaffected normal tissues are required with age- and gender-matched control tissues. Data management is vital to store and retrieve quality control measures, clinical and pathologic data linked to the biospecimens. Customized solutions for managing the acquisition and long-term storage of high-quality brain and tissue biospecimens is necessary to support neuroscience research programs, biomarker discovery and genome scale technologies. Biorepositories that operate according to best-practice policies and procedures guarantee the final wish of the families who donate tissue to support neuroscience research and discovery science.

Original languageEnglish (US)
Title of host publicationBrain Banking
EditorsIngeborg Huitinga, Maree J. Webster
PublisherElsevier B.V.
Number of pages10
ISBN (Print)9780444636393
StatePublished - 2018

Publication series

NameHandbook of Clinical Neurology
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152


  • RNA integrity
  • biomarker discovery
  • brain repository
  • donor recruitment
  • postmortem interval

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)


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