A region of the Herpesvirus saimiri genome required for oncogenicity

Ronald Charles Desrosiers, A. Bakker, J. Kamine, L. A. Falk, R. D. Hunt, N. W. King

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalScience
Volume228
Issue number4696
DOIs
StatePublished - 1985
Externally publishedYes

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Saimiriine Herpesvirus 2
Saimiri
Aotus trivirgatus
Aotidae
Genome
T-Cell Lymphoma
Viral Genome
Herpesviridae
Virus Replication
Primates
Infection

ASJC Scopus subject areas

  • General

Cite this

Desrosiers, R. C., Bakker, A., Kamine, J., Falk, L. A., Hunt, R. D., & King, N. W. (1985). A region of the Herpesvirus saimiri genome required for oncogenicity. Science, 228(4696), 184-187. https://doi.org/10.1126/science.2983431

A region of the Herpesvirus saimiri genome required for oncogenicity. / Desrosiers, Ronald Charles; Bakker, A.; Kamine, J.; Falk, L. A.; Hunt, R. D.; King, N. W.

In: Science, Vol. 228, No. 4696, 1985, p. 184-187.

Research output: Contribution to journalArticle

Desrosiers, RC, Bakker, A, Kamine, J, Falk, LA, Hunt, RD & King, NW 1985, 'A region of the Herpesvirus saimiri genome required for oncogenicity', Science, vol. 228, no. 4696, pp. 184-187. https://doi.org/10.1126/science.2983431
Desrosiers, Ronald Charles ; Bakker, A. ; Kamine, J. ; Falk, L. A. ; Hunt, R. D. ; King, N. W. / A region of the Herpesvirus saimiri genome required for oncogenicity. In: Science. 1985 ; Vol. 228, No. 4696. pp. 184-187.
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