A region of the Herpesvirus saimir genome required for oncogenicity

Ronald C. Desrosiers; Anke Bakker; James Kamine; Lawrence A. Falk; Ronald D. Hunt; Norval W. King

doi:10.1126/science.2983431

A region of the Herpesvirus saimir genome required for oncogenicity

Ronald C. Desrosiers, Anke Bakker, James Kamine, Lawrence A. Falk, Ronald D. Hunt, Norval W. King

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Abstract

Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

Original language	English (US)
Pages (from-to)	184-187
Number of pages	4
Journal	Science
Volume	228
Issue number	4696
DOIs	https://doi.org/10.1126/science.2983431
State	Published - 1985
Externally published	Yes

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title = "A region of the Herpesvirus saimir genome required for oncogenicity",

abstract = "Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.",

author = "Desrosiers, {Ronald C.} and Anke Bakker and James Kamine and Falk, {Lawrence A.} and Hunt, {Ronald D.} and King, {Norval W.}",

year = "1985",

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pages = "184--187",

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AU - Desrosiers, Ronald C.

AU - Bakker, Anke

AU - Kamine, James

AU - Falk, Lawrence A.

AU - Hunt, Ronald D.

AU - King, Norval W.

PY - 1985

Y1 - 1985

N2 - Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

AB - Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

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A region of the Herpesvirus saimir genome required for oncogenicity

Abstract

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