A region of the Herpesvirus saimir genome required for oncogenicity

Ronald C. Desrosiers; Anke Bakker; James Kamine; Lawrence A. Falk; Ronald D. Hunt; Norval W. King

doi:10.1126/science.2983431

A region of the Herpesvirus saimir genome required for oncogenicity

Ronald C. Desrosiers, Anke Bakker, James Kamine, Lawrence A. Falk, Ronald D. Hunt, Norval W. King

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88 Scopus citations

Abstract

Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

Original language	English (US)
Pages (from-to)	184-187
Number of pages	4
Journal	Science
Volume	228
Issue number	4696
DOIs	https://doi.org/10.1126/science.2983431
State	Published - Jan 1 1985
Externally published	Yes

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Desrosiers, R. C., Bakker, A., Kamine, J., Falk, L. A., Hunt, R. D., & King, N. W. (1985). A region of the Herpesvirus saimir genome required for oncogenicity. Science, 228(4696), 184-187. https://doi.org/10.1126/science.2983431

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10.1126/science.2983431