A region of the Herpesvirus saimir genome required for oncogenicity

Ronald C. Desrosiers, Anke Bakker, James Kamine, Lawrence A. Falk, Ronald D. Hunt, Norval W. King

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalScience
Volume228
Issue number4696
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • General

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