A region of the Herpesvirus saimir genome required for oncogenicity

Ronald C. Desrosiers; Anke Bakker; James Kamine; Lawrence A. Falk; Ronald D. Hunt; Norval W. King

doi:10.1126/science.2983431

A region of the Herpesvirus saimir genome required for oncogenicity

Ronald C. Desrosiers, Anke Bakker, James Kamine, Lawrence A. Falk, Ronald D. Hunt, Norval W. King

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

Original language	English (US)
Pages (from-to)	184-187
Number of pages	4
Journal	Science
Volume	228
Issue number	4696
DOIs	https://doi.org/10.1126/science.2983431
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.2983431

Fingerprint Dive into the research topics of 'A region of the Herpesvirus saimir genome required for oncogenicity'. Together they form a unique fingerprint.

Cite this

@article{b8c80ef702694023bcc36b5ed0ee952c,

title = "A region of the Herpesvirus saimir genome required for oncogenicity",

abstract = "Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.",

author = "Desrosiers, {Ronald C.} and Anke Bakker and James Kamine and Falk, {Lawrence A.} and Hunt, {Ronald D.} and King, {Norval W.}",

year = "1985",

doi = "10.1126/science.2983431",

language = "English (US)",

volume = "228",

pages = "184--187",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4696",

}

TY - JOUR

T1 - A region of the Herpesvirus saimir genome required for oncogenicity

AU - Desrosiers, Ronald C.

AU - Bakker, Anke

AU - Kamine, James

AU - Falk, Lawrence A.

AU - Hunt, Ronald D.

AU - King, Norval W.

PY - 1985

Y1 - 1985

N2 - Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

AB - Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.

UR - http://www.scopus.com/inward/record.url?scp=0021906499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021906499&partnerID=8YFLogxK

U2 - 10.1126/science.2983431

DO - 10.1126/science.2983431

M3 - Article

C2 - 2983431

AN - SCOPUS:0021906499

VL - 228

SP - 184

EP - 187

JO - Science

JF - Science

SN - 0036-8075

IS - 4696

ER -