A reduced dose of zidovudine in patients with AIDS

Raymond C.y. Chung, S. Escolano, J. L. Golmard, A. Mallet, Margaret A. Fischl, Anastasios Tsiatis, Ann C. Collier, Teresa Tartaglione, Lawrence Corey

Research output: Contribution to journalLetterpeer-review

9 Scopus citations


To the Editor: The article by Fischl et al. (Oct. 11 issue)* is a very important contribution to the literature on the use of zidovudine in patients with the acquired immunodeficiency syndrome (AIDS). The data presented have already substantially affected the day-to-day care of patients with human immunodeficiency virus (HIV) infection. The study was designed to use an intention-to-treat analysis of the data. Was there a difference in the incidence of opportunistic infections and death between the standard-treatment group and the low-dose group when the results for those who remained on therapy were analyzed? This question is important, because patients.

Original languageEnglish (US)
Pages (from-to)994-996
Number of pages3
JournalNew England Journal of Medicine
Issue number14
StatePublished - Apr 4 1991

ASJC Scopus subject areas

  • Medicine(all)


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