A rationale for combining acetaminophen and NSAIDs for mild-to-moderate pain

Roy D Altman

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Analgesic therapy that combines individual agents with different mechanisms of action has potential advantages for the management of mild-to-moderate pain in the outpatient setting. Theoretically, this approach can lead to greater efficacy and fewer adverse events. While the precise mechanism of action for the analgesic effect of acetaminophen remains uncertain, accumulating evidence suggests that its activity resides primarily in the central nervous system. In contrast, the site of action for the analgesic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is predominantly peripheral, within injured or inflamed tissue. Several controlled clinical studies among patients with musculoskeletal conditions, dental pain, or postoperative pain have shown that combinations of acetaminophen and NSAIDs provide additive pain-relieving activity, thereby leading to dose-sparing effects and improved safety. Further studies are warranted to determine the clinical utility and safety of acetaminophen/ NSAID combinations as analgesic therapy for common conditions associated with mild-to-moderate pain.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalClinical and Experimental Rheumatology
Volume22
Issue number1
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Acetaminophen
Analgesics
Anti-Inflammatory Agents
Pain
Pharmaceutical Preparations
Safety
Drug Combinations
Postoperative Pain
Action Potentials
Tooth
Outpatients
Central Nervous System
Therapeutics

Keywords

  • Acetaminophen
  • Cyclooxygenase inhibitors
  • NSAIDs
  • Pain
  • Prostaglandins

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

A rationale for combining acetaminophen and NSAIDs for mild-to-moderate pain. / Altman, Roy D.

In: Clinical and Experimental Rheumatology, Vol. 22, No. 1, 01.2004, p. 110-117.

Research output: Contribution to journalArticle

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