A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature

Inna V. Fedorenko, Brittany Evernden, Rajappa S. Kenchappa, Solmaz Sahebjam, Elena Ryzhova, John Puskas, Linda McIntosh, Gisela Caceres, Anthony Magliocco, Arnold Etame, J. William Harbour, Keiran S M Smalley, Peter A. Forsyth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Uveal melanoma is a rare subtype of melanoma, accounting for only 3–5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

Original languageEnglish (US)
JournalMelanoma Research
DOIs
StateAccepted/In press - Jun 9 2016

Fingerprint

Meningeal Carcinomatosis
Neoplasm Metastasis
Melanoma
Circulating Neoplastic Cells
Cerebrospinal Fluid
Uveal melanoma
Liver
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Dermatology

Cite this

Fedorenko, I. V., Evernden, B., Kenchappa, R. S., Sahebjam, S., Ryzhova, E., Puskas, J., ... Forsyth, P. A. (Accepted/In press). A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature. Melanoma Research. https://doi.org/10.1097/CMR.0000000000000274

A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma : case report and review of literature. / Fedorenko, Inna V.; Evernden, Brittany; Kenchappa, Rajappa S.; Sahebjam, Solmaz; Ryzhova, Elena; Puskas, John; McIntosh, Linda; Caceres, Gisela; Magliocco, Anthony; Etame, Arnold; William Harbour, J.; Smalley, Keiran S M; Forsyth, Peter A.

In: Melanoma Research, 09.06.2016.

Research output: Contribution to journalArticle

Fedorenko, IV, Evernden, B, Kenchappa, RS, Sahebjam, S, Ryzhova, E, Puskas, J, McIntosh, L, Caceres, G, Magliocco, A, Etame, A, William Harbour, J, Smalley, KSM & Forsyth, PA 2016, 'A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature', Melanoma Research. https://doi.org/10.1097/CMR.0000000000000274
Fedorenko, Inna V. ; Evernden, Brittany ; Kenchappa, Rajappa S. ; Sahebjam, Solmaz ; Ryzhova, Elena ; Puskas, John ; McIntosh, Linda ; Caceres, Gisela ; Magliocco, Anthony ; Etame, Arnold ; William Harbour, J. ; Smalley, Keiran S M ; Forsyth, Peter A. / A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma : case report and review of literature. In: Melanoma Research. 2016.
@article{64817ea0e22c4a8fb0a138c198ac95bc,
title = "A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature",
abstract = "Uveal melanoma is a rare subtype of melanoma, accounting for only 3–5{\%} of all melanoma cases in the USA. Although fewer than 4{\%} of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90{\%} of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.",
author = "Fedorenko, {Inna V.} and Brittany Evernden and Kenchappa, {Rajappa S.} and Solmaz Sahebjam and Elena Ryzhova and John Puskas and Linda McIntosh and Gisela Caceres and Anthony Magliocco and Arnold Etame and {William Harbour}, J. and Smalley, {Keiran S M} and Forsyth, {Peter A.}",
year = "2016",
month = "6",
day = "9",
doi = "10.1097/CMR.0000000000000274",
language = "English (US)",
journal = "Melanoma Research",
issn = "0960-8931",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma

T2 - case report and review of literature

AU - Fedorenko, Inna V.

AU - Evernden, Brittany

AU - Kenchappa, Rajappa S.

AU - Sahebjam, Solmaz

AU - Ryzhova, Elena

AU - Puskas, John

AU - McIntosh, Linda

AU - Caceres, Gisela

AU - Magliocco, Anthony

AU - Etame, Arnold

AU - William Harbour, J.

AU - Smalley, Keiran S M

AU - Forsyth, Peter A.

PY - 2016/6/9

Y1 - 2016/6/9

N2 - Uveal melanoma is a rare subtype of melanoma, accounting for only 3–5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

AB - Uveal melanoma is a rare subtype of melanoma, accounting for only 3–5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

UR - http://www.scopus.com/inward/record.url?scp=84973546881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973546881&partnerID=8YFLogxK

U2 - 10.1097/CMR.0000000000000274

DO - 10.1097/CMR.0000000000000274

M3 - Article

C2 - 27285292

AN - SCOPUS:84973546881

JO - Melanoma Research

JF - Melanoma Research

SN - 0960-8931

ER -