A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature

Inna V. Fedorenko, Brittany Evernden, Rajappa S. Kenchappa, Solmaz Sahebjam, Elena Ryzhova, John Puskas, Linda McIntosh, Gisela Caceres, Anthony Magliocco, Arnold Etame, J. William Harbour, Keiran S M Smalley, Peter A. Forsyth

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1 Scopus citations

Abstract

Uveal melanoma is a rare subtype of melanoma, accounting for only 3–5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

Original languageEnglish (US)
JournalMelanoma Research
DOIs
StateAccepted/In press - Jun 9 2016

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Dermatology

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    Fedorenko, I. V., Evernden, B., Kenchappa, R. S., Sahebjam, S., Ryzhova, E., Puskas, J., McIntosh, L., Caceres, G., Magliocco, A., Etame, A., William Harbour, J., Smalley, K. S. M., & Forsyth, P. A. (Accepted/In press). A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature. Melanoma Research. https://doi.org/10.1097/CMR.0000000000000274