A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting

Tong J. Gan, Christian C. Apfel, Anthony Kovac, Beverly K. Philip, Neil Singla, Harold Minkowitz, Ashraf S. Habib, Jennifer Knighton, Alexandra D. Carides, Hong Zhang, Kevin J. Horgan, Judith K. Evans, Francasca C. Lawson, Farshad Ahadian, David Andres, J. Todd S. Blood, Keith Allen Candiotti, Jacques E. Chelly, Paul Cook, Robert D'AngeloDonald Edmondson, Lee A. Fleisher, Joo Gan Tong, Ralf Gebhard, Kevin Gingrich, Jeffrey A. Grass, Scott Groudine, John Hatridge, Timothy Houden, Michael B. Howie, Piotr K. Janicki, Daniel Katz, Bupesh Kaul, Robert Knapp, Anthony L. Kovac, Kathryn K. Lauer, J. Lance Lichtor, Timothy Melson, Kelly Myers, Peter H. Norman, Michael H. Pearman, James Philip, Neil K. Singla, Marvin Tark, Paul F. White, Thomas A. Witkowski

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

BACKGROUND: Antiemetics currently in use are not totally effective. Neurokinin-1 receptor antagonists are a new class of antiemetic that have shown promise for chemotherapy-induced nausea and vomiting. This is the first study evaluating the efficacy and tolerability of the neurokinin-1 receptor antagonist, aprepitant, for the prevention of postoperative nausea and vomiting. METHODS: In this multicenter, double-blind trial, we randomly assigned 805 patients receiving general anesthesia for open abdominal surgery to a preoperative dose of aprepitant 40 mg orally, aprepitant 125 mg orally, or ondansetron 4 mg IV. Vomiting, nausea, and use of rescue therapy were assessed over 48 h after surgery. Treatments were compared using logistic regression. RESULTS: Incidence rates for the primary end point (complete response [no vomiting and no use of rescue] over 0-24 h after surgery, tested for superiority of aprepitant) were not different across groups (45% with aprepitant 40 mg, 43% with aprepitant 125 mg, and 42% with ondansetron). The incidence of no vomiting (0-24 h) was higher with aprepitant 40 mg (90%) and aprepitant 125 mg (95%) versus ondansetron (74%) (P < 0.001 for both comparisons), although between-treatment use of rescue and nausea control was not different. Both aprepitant doses also had higher incidences of no vomiting over 0-48 h (P < 0.001). No statistically significant differences were seen among the side effect profiles of the treatments. CONCLUSIONS: Aprepitant was superior to ondansetron for prevention of vomiting in the first 24 and 48 h, but no significant differences were observed between aprepitant and ondansetron for nausea control, use of rescue, or complete response.

Original languageEnglish (US)
Pages (from-to)1082-1089
Number of pages8
JournalAnesthesia and analgesia
Volume104
Issue number5
DOIs
StatePublished - May 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Gan, T. J., Apfel, C. C., Kovac, A., Philip, B. K., Singla, N., Minkowitz, H., Habib, A. S., Knighton, J., Carides, A. D., Zhang, H., Horgan, K. J., Evans, J. K., Lawson, F. C., Ahadian, F., Andres, D., Blood, J. T. S., Candiotti, K. A., Chelly, J. E., Cook, P., ... Witkowski, T. A. (2007). A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting. Anesthesia and analgesia, 104(5), 1082-1089. https://doi.org/10.1213/01.ane.0000263277.35140.a3