A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors

Richard R. Reich, Cecile A. Lengacher, Thomas W. Klein, Cathy Newton, Steve Shivers, Sophia Ramesar, Carissa B. Alinat, Carly Paterson, Alice Le, Jong Y. Park, Versie Johnson-Mallard, Maya Elias, Manolete Moscoso, Matthew Goodman, Kevin E. Kip

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Purpose: The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS). Method: A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6 and 12 weeks, 10 ml of venous blood and demographic and clinical data were collected and/or updated. Plasma cytokines (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor [TNF] α, transforming growth factor [TGF] β1, soluble tumor necrosis factor receptor [sTNFR] 1) were assayed. Linear mixed models were used to assess cytokine levels across three time points (baseline and 6 and 12 weeks) by group (MBSR[BC] vs. UC). Results: Of the six measured cytokines, three were nondetectable at rates greater than 50% (IL-10, IL-1β, TGF-β1) and, because of overall low prevalence, were not analyzed further. For the remaining cytokines (TNFα, IL-6, sTNFR1), results showed that TNFα and IL-6 increased during the follow-up period (between 6 and 12 weeks) rather than during the MBSR(BC) training period (between baseline and 6 weeks), while sTNFR1 levels did not change significantly across the 12-week period. Conclusions: Study results suggest that MBSR(BC) affects cytokine levels in BCS, mainly with increases in TNFα and IL-6. The data further suggest that B-cell modulation may be a part of immune recovery during breast cancer management and that increases in TNFα and IL-6 may be markers for MBSR(BC)-related recovery.

Original languageEnglish (US)
Pages (from-to)456-464
Number of pages9
JournalBiological Research For Nursing
Volume19
Issue number4
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

Keywords

  • biomarkers
  • breast cancer
  • cytokines
  • MBSR(BC)
  • Mindfulness-Based Stress Reduction

ASJC Scopus subject areas

  • Research and Theory

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